3-(4-chlorophenyl)-2,3,4,7-tetrahydro-1H-azepine monoformate

Base Information

Chemical Name:3-(4-chlorophenyl)-2,3,4,7-tetrahydro-1H-azepine monoformate
CAS No.:1413938-74-5
Molecular Formula:CH₂O₂*C₁₂H₁₄ClN
Molecular Weight:253.729
Hs Code.:

Synonyms:

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Chemical Property of 3-(4-chlorophenyl)-2,3,4,7-tetrahydro-1H-azepine monoformate

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Technology Process of 3-(4-chlorophenyl)-2,3,4,7-tetrahydro-1H-azepine monoformate

There total 4 articles about 3-(4-chlorophenyl)-2,3,4,7-tetrahydro-1H-azepine monoformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426828-61-6
C₁₅H₁₈ClNO

: 1413938-74-5
3-(4-chlorophenyl)-2,3,4,7-tetrahydro-1H-azepine monoformate

Guidance literature:: Multi-step reaction with 3 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 40 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice; Reflux

3: carbonochloridic acid 1-chloro-ethyl ester / toluene / Cooling with ice; Reflux

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; In tetrahydrofuran; toluene;
DOI:10.1021/ml300262e

Reference yield:

: 1413938-96-1
C₁₃H₁₄ClNO

: 1413938-74-5
3-(4-chlorophenyl)-2,3,4,7-tetrahydro-1H-azepine monoformate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice; Reflux

2: carbonochloridic acid 1-chloro-ethyl ester / toluene / Cooling with ice; Reflux

With lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; In tetrahydrofuran; toluene;
DOI:10.1021/ml300262e

Reference yield:

: 51230-92-3
2-(4-chlorophenyl)pent-4-enoic acid

: 1413938-74-5
3-(4-chlorophenyl)-2,3,4,7-tetrahydro-1H-azepine monoformate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; 2-chloro-1-methyl-pyridinium iodide / dichloromethane / 20 °C

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 40 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice; Reflux

4: carbonochloridic acid 1-chloro-ethyl ester / toluene / Cooling with ice; Reflux

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; 2-chloro-1-methyl-pyridinium iodide; triethylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ml300262e