tert-butyl (S,E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(3-oxomorpholino)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

Base Information

Chemical Name:tert-butyl (S,E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(3-oxomorpholino)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate
CAS No.:1430112-80-3
Molecular Formula:C₃₅H₃₃ClFN₇O₆
Molecular Weight:702.142
Hs Code.:

tert-butyl (S,E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(3-oxomorpholino)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

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Chemical Property of tert-butyl (S,E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(3-oxomorpholino)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

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Technology Process of tert-butyl (S,E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(3-oxomorpholino)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

There total 14 articles about tert-butyl (S,E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(3-oxomorpholino)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₃₃ClFN₇O₆

: 1430112-80-3
tert-butyl (S,E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(3-oxomorpholino)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

Guidance literature:: With Chiracel OD; In methanol; ethanol; n-heptane; Resolution of racemate;

Reference yield:

: 34784-04-8
5-bromoisoquinoline

: 1430112-80-3
tert-butyl (S,E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(3-oxomorpholino)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

: C₃₅H₃₃ClFN₇O₆

Guidance literature:: Multi-step reaction with 5 steps

1: 1,10-Phenanthroline; copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 24 h / 130 °C / Inert atmosphere

2: platinum(IV) oxide; hydrogen / ethanol / 2844.39 Torr

3: manganese(IV) oxide / dichloromethane; dimethyl sulfoxide / 24 h / 20 °C

4: methanol / 72 h / 55 °C / Sealed tube

5: Chiralpak AD-H / ethanol; isopropyl alcohol; diethylamine / Resolution of racemate

With manganese(IV) oxide; platinum(IV) oxide; copper(l) iodide; 1,10-Phenanthroline; hydrogen; potassium carbonate; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; diethylamine; isopropyl alcohol; 1: |Ullmann Condensation / 4: |Ugi Condensation;
DOI:10.1021/acs.jmedchem.7b01171

Reference yield:

: C₁₃H₁₂N₂O₂

: 1430112-80-3
tert-butyl (S,E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(3-oxomorpholino)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

: C₃₅H₃₃ClFN₇O₆

Guidance literature:: Multi-step reaction with 4 steps

1: platinum(IV) oxide; hydrogen / ethanol / 2844.39 Torr

2: manganese(IV) oxide / dichloromethane; dimethyl sulfoxide / 24 h / 20 °C

3: methanol / 72 h / 55 °C / Sealed tube

4: Chiralpak AD-H / ethanol; isopropyl alcohol; diethylamine / Resolution of racemate

With manganese(IV) oxide; platinum(IV) oxide; hydrogen; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; diethylamine; isopropyl alcohol; 3: |Ugi Condensation;
DOI:10.1021/acs.jmedchem.7b01171