(R)-2-methyl-4-nitrobutanoic acid

Base Information

• Chemical Name: (R)-2-methyl-4-nitrobutanoic acid
• CAS No.: 88390-28-7
• Molecular Formula: C₅H₉NO₄
• Molecular Weight: 147.131
• Hs Code.: 2915900090
• Mol file: 88390-28-7.mol

Synonyms:(R)-2-methyl-4-nitrobutanoic acid;

Chemical Property of (R)-2-methyl-4-nitrobutanoic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.463
• Boiling Point: 307.148 °C at 760 mmHg
• PKA: 4.37±0.10(Predicted)
• Flash Point: 141.993 °C
• PSA: 83.12000
• Density: 1.238 g/cm³
• LogP: 0.89710

Purity/Quality:

98%min ^*data from raw suppliers

(R)-2-METHYL-4-NITROBUTANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-methyl-4-nitrobutanoic acid

There total 3 articles about (R)-2-methyl-4-nitrobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-nitro-2-methyl-3-butanoate → 2-methyl-4-nitrobutanoic acid (88348-06-5,88390-28-7)

Guidance literature:

With water; potassium hydroxide; at 25 ℃; for 24.5h;

Reference yield:

ethyl (2R)-2-methyl-4-oxobutanoate → 2-methyl-4-nitrobutanoic acid (88348-06-5,88390-28-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine / acetonitrile; water / 0.67 h

2: sodium tungstate (VI) dihydrate; urea hydrogen peroxide adduct / methanol / 2 h / 50 °C

3: potassium hydroxide; water / 24.5 h / 25 °C

With sodium tungstate (VI) dihydrate; water; hydroxylamine; urea hydrogen peroxide adduct; potassium hydroxide; In methanol; water; acetonitrile;

Reference yield:

ethyl-4-(hydroxyimino)-2-methylbutanoate → 2-methyl-4-nitrobutanoic acid (88348-06-5,88390-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tungstate (VI) dihydrate; urea hydrogen peroxide adduct / methanol / 2 h / 50 °C

2: potassium hydroxide; water / 24.5 h / 25 °C

With sodium tungstate (VI) dihydrate; water; urea hydrogen peroxide adduct; potassium hydroxide; In methanol;

Refernces