(R)-(-)-2-phenyl-3,3-dimethyloxetane

Base Information

• Chemical Name: (R)-(-)-2-phenyl-3,3-dimethyloxetane
• CAS No.: 167032-11-3
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.232
• Mol file: 167032-11-3.mol

Synonyms:

Chemical Property of (R)-(-)-2-phenyl-3,3-dimethyloxetane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-2-phenyl-3,3-dimethyloxetane

There total 3 articles about (R)-(-)-2-phenyl-3,3-dimethyloxetane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methanesulfonic acid (R)-3-hydroxy-2,2-dimethyl-3-phenyl-propyl ester → (R)-(-)-2-phenyl-3,3-dimethyloxetane (167032-11-3)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; Ambient temperature;

DOI:10.1055/s-1995-3939

Reference yield:

β-Chlor-pivalophenon (4301-07-9) → (R)-(-)-2-phenyl-3,3-dimethyloxetane (167032-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: (R,R')-N,N'-dibenzoylcystine, LiBH₄, t-BuOH / tetrahydrofuran / 9 h

2: 1.) AcCl, pyridine, 2.) KOH

With pyridine; potassium hydroxide; lithium borohydride; N,N′-dibenzoyl-L-cysteine; acetyl chloride; tert-butyl alcohol; In tetrahydrofuran;

DOI:10.1039/c39860001018

Reference yield:

3-Chloro-2,2-dimethyl-1-phenyl-propan-1-ol → (R)-(-)-2-phenyl-3,3-dimethyloxetane (167032-11-3) + (S)-(+)-3,3-dimethyl-2-phenyl-oxetane (106727-03-1)

Guidance literature:

With pyridine; potassium hydroxide; acetyl chloride; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1039/c39860001018

upstream raw materials:

β-Chlor-pivalophenon

Downstream raw materials:

(R)-(-)-3-methoxy-2,2-dimethyl-3-phenylpropanol

(S)-(+)-3-methoxy-2,2-dimethyl-3-phenylpropanol