（s）-1-benzyl-2-methyl-4，4-difluoropyrrolidine-1，2-dicarb

Base Information

Chemical Name:（s）-1-benzyl-2-methyl-4，4-difluoropyrrolidine-1，2-dicarb
CAS No.:72180-26-8
Molecular Formula:C14H15 F2 N O4
Molecular Weight:299.274
Hs Code.:2933990090
Mol file:72180-26-8.mol

Synonyms:1,2-Pyrrolidinedicarboxylicacid, 4,4-difluoro-, 2-methyl 1-(phenylmethyl) ester,(S)-

Suppliers and Price of （s）-1-benzyl-2-methyl-4，4-difluoropyrrolidine-1，2-dicarb

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
(S)-1-Benzyl-2-methyl-4,4-difluoropyrrolidine-1,2-dicarboxylic acid 92%
1g
$ 998.00

Crysdot
(S)-1-BEnzyl-2-methyl-4,4-difluoropyrrolidine-1,2-dicarboxylicacid 95+%
1g
$ 618.00

American Custom Chemicals Corporation
(S)-1-BENZYL 2-METHYL 4,4-DIFLUOROCYCLOPENTANE-1,2-DICARBOXYLATE 95.00%
1G
$ 1674.75

AK Scientific
(S)-1-Benzyl-2-methyl-4,4-difluoropyrrolidine-1,2-dicarboxylicacid
1g
$ 1397.00

Total 9 raw suppliers

Chemical Property of （s）-1-benzyl-2-methyl-4，4-difluoropyrrolidine-1，2-dicarb

Chemical Property:

Boiling Point:378.2±42.0 °C(Predicted)
PKA:-8.05±0.60(Predicted)
PSA：55.84000
Density:1.31±0.1 g/cm3(Predicted)
LogP:2.14370

Purity/Quality:

98%min ^*data from raw suppliers

(S)-1-Benzyl-2-methyl-4,4-difluoropyrrolidine-1,2-dicarboxylic acid 92% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of （s）-1-benzyl-2-methyl-4，4-difluoropyrrolidine-1，2-dicarb

There total 3 articles about （s）-1-benzyl-2-methyl-4，4-difluoropyrrolidine-1，2-dicarb which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64187-47-9
1-benzyloxycarbonyl-4-keto-L-proline

: 72180-26-8
4,4-difluoro-1-<(phenylmethoxy)carbonyl>-L-proline methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 0 °C

2: (diethylamido)sulfur trifluoride (DAST) / CH₂Cl₂ / 16 h / Ambient temperature

With (diethylamido)sulfur trifluoride; In diethyl ether; dichloromethane;
DOI:10.1021/jm00167a028

Reference yield:

: 16217-15-5
1-benzyloxycarbonyl-4-oxo-L-proline methyl ester

: 72180-26-8
4,4-difluoro-1-<(phenylmethoxy)carbonyl>-L-proline methyl ester

Guidance literature:: With (diethylamido)sulfur trifluoride; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1021/jm00167a028

Reference yield:

: N-Cbz-cis-4-hydroxyl-L-methyl prolinate

: 72180-26-8
4,4-difluoro-1-<(phenylmethoxy)carbonyl>-L-proline methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.5 h / 0 - 15 °C

2: diethylamino-sulfur trifluoride / ethanol; dichloromethane / 12 h / 0 - 15 °C

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; diethylamino-sulfur trifluoride; trichloroisocyanuric acid; In ethanol; dichloromethane;