(5-CHLORO-2-METHOXYPYRIDIN-3-YL)BORONIC ACID

Base Information

• Chemical Name: (5-CHLORO-2-METHOXYPYRIDIN-3-YL)BORONIC ACID
• CAS No.: 943153-22-8
• Molecular Formula: C6H7BClNO3
• Molecular Weight: 187.39
• Hs Code.: 2933399090
• Mol file: 943153-22-8.mol

Synonyms:(5-Chloro-2-methoxypyridin-3-yl)boronicacid;boronic acid, B-(5-chloro-2-methoxy-3-pyridinyl)-;5-Chloro-2-methoxypyridine-3-boronic acid;

Chemical Property of (5-CHLORO-2-METHOXYPYRIDIN-3-YL)BORONIC ACID

Chemical Property:

• Melting Point: 148-152ºC
• Refractive Index: 1.545
• Boiling Point: 353.1 °C at 760 mmHg
• PKA: 5.93±0.58(Predicted)
• Flash Point: 167.3 °C
• PSA: 62.58000
• Density: 1.4 g/cm³
• LogP: -0.57660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-2-methoxypyridine-3-boronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Chloro-2-methoxypyridine-3-boronic Acid is a useful research chemical compound used in the preparation of triazine derivatives as inhibitors of phosphodiesterases for treating CNS disorders, metabolic disorders, and other diseases.

Technology Process of (5-CHLORO-2-METHOXYPYRIDIN-3-YL)BORONIC ACID

There total 1 articles about (5-CHLORO-2-METHOXYPYRIDIN-3-YL)BORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

→ (5-chloro-2-methoxypyridin-3-yl)boronic acid (943153-22-8)

Guidance literature:

Reference yield: 100.0%

(5-chloro-2-methoxypyridin-3-yl)boronic acid (943153-22-8) + (R)-1-(4-bromophenyl)ethylamine (24358-62-1,27298-97-1,45791-36-4,64313-06-0) → (R)-1-[4-(5-chloro-2-methoxypyridin-3-yl)-phenyl]-ethylamine (943153-26-2)

Guidance literature:

palladium diacetate; In water; at 180 ℃; for 0.116667h; Product distribution / selectivity; Irradiation;

Reference yield: 23.12%

(5-chloro-2-methoxypyridin-3-yl)boronic acid (943153-22-8) + (P)-1-(4-bromo-5-fluoro-2-methoxyphenyl)-N-(isoxazol-3-yl)-2-oxo-1,2-dihydroquinoline-6-sulfonamide → (P)-1-(4-(5-chloro-2-methoxy-3-pyridinyl)-5-fluoro-2-methoxyphenyl)-N-3-isoxazolyl-2-oxo-1,2-dihydro-6-quinolinesulfonamide

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 50 ℃; for 18h; Inert atmosphere;

Downstream raw materials:

(R)-1-[4-(5-chloro-2-methoxypyridin-3-yl)-phenyl]-ethylamine

[4-(5-chloro-2-methoxy-pyridin-3-yl)-3-methoxy-benzyl]-carbamic acid tert-butyl ester

[4-(5-chloro-2-methoxypyridin-3-yl)-3-trifluoromethoxy-benzyl]-carbamic acid-tert-butyl ester

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