(2S,12bR)-(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinolizin-2-yl)-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Base Information

Chemical Name:(2S,12bR)-(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinolizin-2-yl)-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester
CAS No.:1025907-17-8
Molecular Formula:C₃₃H₄₂N₂O₂
Molecular Weight:498.709
Hs Code.:

(2S,12bR)-(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinolizin-2-yl)-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

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Chemical Property of (2S,12bR)-(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinolizin-2-yl)-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

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Technology Process of (2S,12bR)-(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinolizin-2-yl)-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

There total 9 articles about (2S,12bR)-(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinolizin-2-yl)-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-[(1R,2S,5R)-5-Methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonylmethyl]-2,3,4,6,7,12-hexahydro-1H-indolo[2,3-a]quinolizin-5-ylium; chloride

: 1025907-17-8
(2S,12bR)-(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinolizin-2-yl)-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h;

Reference yield:

: 189265-57-4
(E)-5-(2-Bromo-1-ethoxy-ethoxy)-pent-2-enoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

: 1025907-17-8
(2S,12bR)-(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinolizin-2-yl)-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) Bu₃SnH, methylaluminum bis(2,6-di-tert-butyl-4-methylphenoxide); 2.) Et₃B / 1.) toluene, -40 deg C, 30 min; 2.) toluene, hexane, -40 deg C, 1.5 h

2: 1.) 10percent HClO₄; 2.) Ag₂CO₃-celite / 1.) THF, 24 h, RT; 2.) benzene, reflux, 40 min

3: 72 percent / toluene / 7 h / Heating

4: Et₃N / benzene / 1 h / Ambient temperature

5: KH, 18-crown-6 / 1,2-dimethoxy-ethane / 1.5 h

6: POCl₃ / acetonitrile / 1.5 h / Heating

7: NaBH₄ / methanol / 1 h / 0 °C

With sodium tetrahydroborate; perchloric acid; 18-crown-6 ether; triethyl borane; tri-n-butyl-tin hydride; potassium hydride; bis(2,6-di-tert-butyl-4-methylphenoxide)methylaluminum; triethylamine; silver carbonate; trichlorophosphate; In methanol; 1,2-dimethoxyethane; toluene; acetonitrile; benzene;

Reference yield:

: 189265-58-5
(+)-(1'R,3'R,4'S)-8'-Phenyl-p-menthan-3'-yl(4S)-2-oxo-3,4,5,6-tetrahydro-2H-pyran-4-ylacetate

: 1025907-17-8
(2S,12bR)-(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinolizin-2-yl)-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / toluene / 7 h / Heating

2: Et₃N / benzene / 1 h / Ambient temperature

3: KH, 18-crown-6 / 1,2-dimethoxy-ethane / 1.5 h

4: POCl₃ / acetonitrile / 1.5 h / Heating

5: NaBH₄ / methanol / 1 h / 0 °C

With sodium tetrahydroborate; 18-crown-6 ether; potassium hydride; triethylamine; trichlorophosphate; In methanol; 1,2-dimethoxyethane; toluene; acetonitrile; benzene;