Boc-D-Pyroglutaminol

Base Information

Chemical Name:Boc-D-Pyroglutaminol
CAS No.:128811-37-0
Molecular Formula:C₁₀H₁₇NO₄
Molecular Weight:215.249
Hs Code.:29225090
DSSTox Substance ID:DTXSID10526322
Wikidata:Q72503352
Mol file:128811-37-0.mol

Synonyms:Boc-D-Pyroglutaminol;128811-37-0;TERT-BUTYL (2R)-2-(HYDROXYMETHYL)-5-OXOPYRROLIDINE-1-CARBOXYLATE;(R)-tert-Butyl 2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-5-oxo-, 1,1-dimethylethyl ester, (2R)-;MFCD12911763;SCHEMBL13482907;DTXSID10526322;tert-butyl (r)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate;FD1016;AKOS015917865;AC-23790;DS-14336;CS-0154804;tert-Butyl(2R)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate

Suppliers and Price of Boc-D-Pyroglutaminol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Boc-D-Pyroglutaminol 95+%
5g
$ 350.00

Chemenu
tert-butyl(R)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate 95%
5g
$ 785.00

Chemenu
tert-butyl(R)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate 95%
1g
$ 262.00

American Custom Chemicals Corporation
BOC-D-PYROGLUTAMINOL 95.00%
5G
$ 582.75

American Custom Chemicals Corporation
BOC-D-PYROGLUTAMINOL 95.00%
5MG
$ 498.99

Ambeed
Boc-D-Pyroglutaminol 97%
5g
$ 125.00

Ambeed
Boc-D-Pyroglutaminol 97%
1g
$ 51.00

Ambeed
Boc-D-Pyroglutaminol 97%
250mg
$ 20.00

Acrotein
(R)-1-Boc-2-(hydroxymethyl)-5-oxopyrrolidine 97%
5g
$ 307.08

ACHEMBLOCK
(R)-1-Boc-2-(hydroxymethyl)-5-oxopyrrolidine 95%
5G
$ 605.00

Total 39 raw suppliers

Chemical Property of Boc-D-Pyroglutaminol

Chemical Property:

Boiling Point:370.861 °C at 760 mmHg
Flash Point:178.09 °C
PSA：66.84000
Density:1.183 g/cm³
LogP:0.84270
Storage Temp.:2-8°C
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:215.11575802
Heavy Atom Count:15
Complexity:269

Purity/Quality:

99% ^*data from raw suppliers

Boc-D-Pyroglutaminol 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1C(CCC1=O)CO
Isomeric SMILES:CC(C)(C)OC(=O)N1[C@H](CCC1=O)CO

Technology Process of Boc-D-Pyroglutaminol

There total 13 articles about Boc-D-Pyroglutaminol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 128811-31-4
tert-butyl (2R)-2-<<(tert-butyl)dimethylsilyloxy>methyl>-5-oxopyrrolidine-1-carboxylate

: 128811-37-0,344884-10-2
tert-butyl (2R)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In methanol; for 6h; Ambient temperature;
DOI:10.1002/hlca.19900730113

Reference yield:

: 185303-67-7
(R)-N-(tert-butoxycarbonyl)-5-formylpyrrolidin-2-one

: 128811-37-0,344884-10-2
tert-butyl (2R)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate

Guidance literature:: With sodium tetrahydroborate; In methanol;
DOI:10.1016/S0040-4039(00)76729-3

Reference yield:

: 141293-28-9
N-(tert-butoxycarbonyl)-2-[(tert-butyldimethylsilyl)oxy]pyrrole

: 128811-37-0,344884-10-2
tert-butyl (2R)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / SnCl₄ / diethyl ether / 3 h / -85 °C

2: 92 percent / H₂, AcONa / 10percent Pd/C / tetrahydrofuran / 24 h / Ambient temperature

3: 80percent aq. acetic acid / 8 h / 50 °C

4: aq. NaIO₄, SiO₂ / CH₂Cl₂ / 0.25 h

5: 1.8 g / NaBH₄ / methanol / 2 h / -30 - 0 °C

With sodium tetrahydroborate; sodium periodate; hydrogen; sodium acetate; silica gel; tin(IV) chloride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm960400q