(11aS)-7-methoxy-8-(3-(2-methoxy-5-(4-(6-(4-methoxyphenyl)-2-naphthoyl)piperazine-1-carbonyl)phenoxy)propoxy)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

Base Information

Chemical Name:(11aS)-7-methoxy-8-(3-(2-methoxy-5-(4-(6-(4-methoxyphenyl)-2-naphthoyl)piperazine-1-carbonyl)phenoxy)propoxy)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one
CAS No.:1334136-11-6
Molecular Formula:C₄₆H₄₆N₄O₈
Molecular Weight:782.893
Hs Code.:

(11aS)-7-methoxy-8-(3-(2-methoxy-5-(4-(6-(4-methoxyphenyl)-2-naphthoyl)piperazine-1-carbonyl)phenoxy)propoxy)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

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Chemical Property of (11aS)-7-methoxy-8-(3-(2-methoxy-5-(4-(6-(4-methoxyphenyl)-2-naphthoyl)piperazine-1-carbonyl)phenoxy)propoxy)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

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Technology Process of (11aS)-7-methoxy-8-(3-(2-methoxy-5-(4-(6-(4-methoxyphenyl)-2-naphthoyl)piperazine-1-carbonyl)phenoxy)propoxy)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

There total 12 articles about (11aS)-7-methoxy-8-(3-(2-methoxy-5-(4-(6-(4-methoxyphenyl)-2-naphthoyl)piperazine-1-carbonyl)phenoxy)propoxy)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132292-17-2
6-(4-methoxyphenyl)-2-naphthoic acid

: 1334136-11-6
(11aS)-7-methoxy-8-(3-(2-methoxy-5-(4-(6-(4-methoxyphenyl)-2-naphthoyl)piperazine-1-carbonyl)phenoxy)propoxy)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: potassium carbonate / acetone / Reflux

4.1: potassium carbonate / acetone / Reflux

5.1: tin(II) chloride dihdyrate / methanol / Reflux

5.2: pH 8

6.1: calcium carbonate; mercury dichloride / water; acetonitrile / 12 h / 20 °C

With thionyl chloride; tin(II) chloride dihdyrate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; calcium carbonate; mercury dichloride; In methanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1002/cmdc.201100207

Reference yield:

: 1334137-82-4
ethyl 6-(4-methoxyphenyl)-2-naphthoate

: 1334136-11-6
(11aS)-7-methoxy-8-(3-(2-methoxy-5-(4-(6-(4-methoxyphenyl)-2-naphthoyl)piperazine-1-carbonyl)phenoxy)propoxy)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: water; sodium hydroxide / ethanol / 20 - 80 °C

1.2: pH 7

2.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: potassium carbonate / acetone / Reflux

5.1: potassium carbonate / acetone / Reflux

6.1: tin(II) chloride dihdyrate / methanol / Reflux

6.2: pH 8

7.1: calcium carbonate; mercury dichloride / water; acetonitrile / 12 h / 20 °C

With thionyl chloride; tin(II) chloride dihdyrate; water; potassium carbonate; triethylamine; N,N-dimethyl-formamide; calcium carbonate; mercury dichloride; sodium hydroxide; In methanol; ethanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1002/cmdc.201100207

Reference yield:

: 1334138-60-1
C₅₀H₅₆N₄O₁₀S₂

: 1334136-11-6
(11aS)-7-methoxy-8-(3-(2-methoxy-5-(4-(6-(4-methoxyphenyl)-2-naphthoyl)piperazine-1-carbonyl)phenoxy)propoxy)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tin(II) chloride dihdyrate / methanol / Reflux

1.2: pH 8

2.1: calcium carbonate; mercury dichloride / water; acetonitrile / 12 h / 20 °C

With tin(II) chloride dihdyrate; calcium carbonate; mercury dichloride; In methanol; water; acetonitrile;
DOI:10.1002/cmdc.201100207