Technology Process of (11aS)-7-methoxy-8-(3-(2-methoxy-5-(4-(6-(4-methoxyphenyl)-2-naphthoyl)piperazine-1-carbonyl)phenoxy)propoxy)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one
There total 12 articles about (11aS)-7-methoxy-8-(3-(2-methoxy-5-(4-(6-(4-methoxyphenyl)-2-naphthoyl)piperazine-1-carbonyl)phenoxy)propoxy)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 0 - 20 °C
3.1: potassium carbonate / acetone / Reflux
4.1: potassium carbonate / acetone / Reflux
5.1: tin(II) chloride dihdyrate / methanol / Reflux
5.2: pH 8
6.1: calcium carbonate; mercury dichloride / water; acetonitrile / 12 h / 20 °C
With
thionyl chloride; tin(II) chloride dihdyrate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; calcium carbonate; mercury dichloride;
In
methanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1002/cmdc.201100207
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: water; sodium hydroxide / ethanol / 20 - 80 °C
1.2: pH 7
2.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C / Inert atmosphere
3.1: triethylamine / dichloromethane / 0 - 20 °C
4.1: potassium carbonate / acetone / Reflux
5.1: potassium carbonate / acetone / Reflux
6.1: tin(II) chloride dihdyrate / methanol / Reflux
6.2: pH 8
7.1: calcium carbonate; mercury dichloride / water; acetonitrile / 12 h / 20 °C
With
thionyl chloride; tin(II) chloride dihdyrate; water; potassium carbonate; triethylamine; N,N-dimethyl-formamide; calcium carbonate; mercury dichloride; sodium hydroxide;
In
methanol; ethanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1002/cmdc.201100207
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tin(II) chloride dihdyrate / methanol / Reflux
1.2: pH 8
2.1: calcium carbonate; mercury dichloride / water; acetonitrile / 12 h / 20 °C
With
tin(II) chloride dihdyrate; calcium carbonate; mercury dichloride;
In
methanol; water; acetonitrile;
DOI:10.1002/cmdc.201100207