6-[2-(benzyloxy)-6-(hydroxymethyl)-4-methylphenoxy]-3-formyl-2-methoxybenzoic acid

Base Information

Chemical Name:6-[2-(benzyloxy)-6-(hydroxymethyl)-4-methylphenoxy]-3-formyl-2-methoxybenzoic acid
CAS No.:1374139-16-8
Molecular Formula:C₂₄H₂₂O₇
Molecular Weight:422.434
Hs Code.:

Synonyms:

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Chemical Property of 6-[2-(benzyloxy)-6-(hydroxymethyl)-4-methylphenoxy]-3-formyl-2-methoxybenzoic acid

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Technology Process of 6-[2-(benzyloxy)-6-(hydroxymethyl)-4-methylphenoxy]-3-formyl-2-methoxybenzoic acid

There total 18 articles about 6-[2-(benzyloxy)-6-(hydroxymethyl)-4-methylphenoxy]-3-formyl-2-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(benzyloxy)-4-methyl-6-{[(tetrahydro-2H-pyran-2-yl)oxy]methyl}phenol

: 1374139-16-8
6-[2-(benzyloxy)-6-(hydroxymethyl)-4-methylphenoxy]-3-formyl-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; copper; copper(II) oxide / acetonitrile / 12 h / Reflux

2.1: toluene-4-sulfonic acid / water; isopropyl alcohol / Reflux

3.1: toluene-4-sulfonic acid / methanol / 1 h

3.2: 12 h / Reflux

With dmap; copper; toluene-4-sulfonic acid; copper(II) oxide; In methanol; water; isopropyl alcohol; acetonitrile; 1.1: Ullmann condensation;
DOI:10.1002/hlca.201100405

Reference yield:

: 1374139-10-2
3-(benzyloxy)-5-bromo-2-{[(tert-butyl)dimethylsilyl]-oxy}benzaldehyde

: 1374139-16-8
6-[2-(benzyloxy)-6-(hydroxymethyl)-4-methylphenoxy]-3-formyl-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1 h / 110 °C

2.1: sodium tetrahydroborate / methanol / 4 h / 0 - 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 20 °C

4.1: toluene-4-sulfonic acid / dichloromethane / 0.25 h / -20 °C

4.2: 1 h / 0 °C

5.1: dmap; copper; copper(II) oxide / acetonitrile / 12 h / Reflux

6.1: toluene-4-sulfonic acid / water; isopropyl alcohol / Reflux

7.1: toluene-4-sulfonic acid / methanol / 1 h

7.2: 12 h / Reflux

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; tetrabutyl ammonium fluoride; copper; toluene-4-sulfonic acid; copper(II) oxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol; acetonitrile; 1.1: Negishi coupling reaction / 5.1: Ullmann condensation;
DOI:10.1002/hlca.201100405

Reference yield:

: 1374139-14-6
methyl 6-{2-(benzyloxy)-4-methyl-6-{[(tetrahydro-2H-pyran-2-yl)oxy]methyl}phenoxy}-3-formyl-2-methoxybenzoate

: 1374139-16-8
6-[2-(benzyloxy)-6-(hydroxymethyl)-4-methylphenoxy]-3-formyl-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / water; isopropyl alcohol / Reflux

2.1: toluene-4-sulfonic acid / methanol / 1 h

2.2: 12 h / Reflux

With toluene-4-sulfonic acid; In methanol; water; isopropyl alcohol;
DOI:10.1002/hlca.201100405