ETHYL 1-(AMINOMETHYL)CYCLOPENTANECARBOXYLATE

Base Information

• Chemical Name: ETHYL 1-(AMINOMETHYL)CYCLOPENTANECARBOXYLATE
• CAS No.: 99065-34-6
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.239
• Hs Code.: 2922499990
• Mol file: 99065-34-6.mol

Synonyms:ethyl 1-aminomethyl-cyclopentane-1-carboxylate;1-Aethoxycarbonyl-1-aminomethyl-cyclopentan;1-aminomethylcyclopentane-1-carboxylic acid ethyl ester;1-aminomethylcyclopent-1-yl-carboxylic acid ethyl ester;

Chemical Property of ETHYL 1-(AMINOMETHYL)CYCLOPENTANECARBOXYLATE

Chemical Property:

• PSA: 52.32000
• LogP: 1.76890
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

ethyl1-(aminomethyl)cyclopentanecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 1-(AMINOMETHYL)CYCLOPENTANECARBOXYLATE

There total 3 articles about ETHYL 1-(AMINOMETHYL)CYCLOPENTANECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 1-cyanocyclopentanecarboxylate (28247-14-5) → 1-aminomethylcyclopentane-1-carboxylic acid ethyl ester (99065-34-6)

Guidance literature:

With hydrogen; nickel; In ethanol;

Reference yield:

ethyl 1-cyanocyclopentanecarboxylate (28247-14-5) + 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran (96042-30-7) → 1-aminomethylcyclopentane-1-carboxylic acid ethyl ester (99065-34-6)

Guidance literature:

With ammonium hydroxide; ammonia; In methanol; ethanol;

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → 1-aminomethylcyclopentane-1-carboxylic acid ethyl ester (99065-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetonitrile / 96 h / Heating

2: H₂ / 5 percent Rh/Al₂O₃

With hydrogen; potassium carbonate; Rh/Al₂O₃; In acetonitrile; 1: Alkylation / 2: Reduction;

DOI:10.1016/S0960-894X(00)00174-8

upstream raw materials:

ethyl 1-cyanocyclopentanecarboxylate

ethyl 2-cyanoacetate

4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

Downstream raw materials:

ethyl N-[(2'-cyanobiphenyl-4-yl)methyl]-1-aminomethylcyclopentane-1-carboxylate

1-(<<(tert-butoxy)carbonyl>amino>methyl)cyclopentane-1-carboxylic acid

Refernces

• 1、 -. "N-ACYL-N-QUINOLINYL OR ISOQUINOUNYL ALKYLAMINO ACIDS COMPOSITIONS AND METHOD OF USE". . . Retrieved 2008/06/13.
• 2、 -. "N-SUBSTITUTED HETEROCYCLIC DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE PRESENT". . . Retrieved 2008/06/13.