8-Nonenoicacid,2-amino-,(2S)-

Base Information

• Chemical Name: 8-Nonenoicacid,2-amino-,(2S)-
• CAS No.: 924307-76-6
• Molecular Formula: C9H17 N O2
• Molecular Weight: 171.239
• Mol file: 924307-76-6.mol

Synonyms:I04-1190;

Chemical Property of 8-Nonenoicacid,2-amino-,(2S)-

Chemical Property:

• Melting Point: 200-201℃ (DEC.)
• Boiling Point: 303℃
• PKA: 2.54±0.24(Predicted)
• Flash Point: 137℃
• PSA: 63.32000
• Density: 1.002
• LogP: 2.23510
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-2-Aminonon-8-enoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Nonenoicacid,2-amino-,(2S)-

There total 2 articles about 8-Nonenoicacid,2-amino-,(2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(±)-2-acetamido-8-nonenoic acid (924309-93-3) → (S)-2-amino-8-nonenoic acid (924307-76-6,1427467-46-6) + (R)-2-acetamido-8-nonenoic acid (924309-93-3)

Guidance literature:

With Acylase I; cobalt(II) chloride hexahydrate; sodium hydroxide; In water; at 20 - 38.5 ℃; for 7h; pH=7.5 - 7.8;

DOI:10.1021/op0601924

Reference yield:

7-bromo-hept-1-ene (4117-09-3) → (S)-2-amino-8-nonenoic acid (924307-76-6,1427467-46-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate; caesium carbonate / acetonitrile / 24 h / Reflux

2.1: potassium hydroxide / ethanol / 2 h / Reflux

2.2: pH 4 - 5 / Reflux

3.1: citric acid / water / pH 4-5 / Reflux

4.1: sodium hydroxide; cobalt(II) chloride hexahydrate / water / 38.5 °C / Enzymatic reaction

With cobalt(II) chloride hexahydrate; potassium carbonate; caesium carbonate; citric acid; potassium hydroxide; sodium hydroxide; In ethanol; water; acetonitrile;

Reference yield: 100.0%

(S)-2-amino-8-nonenoic acid (924307-76-6,1427467-46-6) + cyclopentyl chloroformate (50715-28-1) → (S)-2-cyclopentyloxycarbonyl-amino-8-nonenoic acid (769167-55-7)

Guidance literature:

With sodium carbonate; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1.08333h;

DOI:10.1021/op0601924

upstream raw materials:

(±)-2-acetamido-8-nonenoic acid

7-bromo-hept-1-ene

Downstream raw materials:

(S)-2-(tert-butoxycarbonylamino)non-8-enoic acid

C₃₃H₄₁BrN₆O₉S₂

C₃₂H₄₄BrN₃O₉S

C₃₀H₄₀BrN₃O₉S

Refernces

• 1、 -. "COMPOUNDS AS HEPATITIS C INHIBITORS AND USES THEREOF IN MEDICINE". . . Retrieved 2016/09/22.