1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine dihydrochloride

Base Information

• Chemical Name: 1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine dihydrochloride
• CAS No.: 106448-37-7
• Molecular Formula: C₂₆H₂₆F₂N₂*2ClH
• Molecular Weight: 477.425
• Mol file: 106448-37-7.mol

Synonyms:

Chemical Property of 1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine dihydrochloride

There total 3 articles about 1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-difluorobenzhydryl alcohol (365-24-2) → 1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine dihydrochloride (27064-95-5,30484-77-6,53114-47-9,106448-37-7)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide

2: acetonitrile

3: potassium carbonate / N,N-dimethyl-formamide

With oxalyl dichloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1124/mol.114.095471

Reference yield:

4,4'-difluorobenzhydryl chloride (27064-94-4) → 1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine dihydrochloride (27064-95-5,30484-77-6,53114-47-9,106448-37-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile

2: potassium carbonate / N,N-dimethyl-formamide

With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1124/mol.114.095471

Reference yield:

1-(4-fluorophenyl)methyl-piperazine (27469-60-9) + 3-bromo-1-phenyl-1-propenyl bromide (4392-24-9) → 1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine dihydrochloride (27064-95-5,30484-77-6,53114-47-9,106448-37-7)

Guidance literature:

1-(4-fluorophenyl)methyl-piperazine; 3-bromo-1-phenyl-1-propenyl bromide; With potassium carbonate; In N,N-dimethyl-formamide;

With hydrogenchloride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1124/mol.114.095471

upstream raw materials:

1-(4-fluorophenyl)methyl-piperazine

3-bromo-1-phenyl-1-propenyl bromide

4,4'-difluorobenzhydryl alcohol

4,4'-difluorobenzhydryl chloride