N-((4aR,5R,11aR)-7-Chloro-1,2,3,4,4a,5,11,11a-octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-4-[4-(4-fluoro-phenyl)-piperazin-1-yl]-butyramide

Base Information

Chemical Name:N-((4aR,5R,11aR)-7-Chloro-1,2,3,4,4a,5,11,11a-octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-4-[4-(4-fluoro-phenyl)-piperazin-1-yl]-butyramide
CAS No.:130953-92-3
Molecular Formula:C₂₈H₃₅ClFN₃OS
Molecular Weight:516.123
Hs Code.:

N-((4aR,5R,11aR)-7-Chloro-1,2,3,4,4a,5,11,11a-octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-4-[4-(4-fluoro-phenyl)-piperazin-1-yl]-butyramide

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Chemical Property of N-((4aR,5R,11aR)-7-Chloro-1,2,3,4,4a,5,11,11a-octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-4-[4-(4-fluoro-phenyl)-piperazin-1-yl]-butyramide

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Technology Process of N-((4aR,5R,11aR)-7-Chloro-1,2,3,4,4a,5,11,11a-octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-4-[4-(4-fluoro-phenyl)-piperazin-1-yl]-butyramide

There total 5 articles about N-((4aR,5R,11aR)-7-Chloro-1,2,3,4,4a,5,11,11a-octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-4-[4-(4-fluoro-phenyl)-piperazin-1-yl]-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130933-30-1
(4aR,11aR)-7-Chloro-2,3,4,4a,11,11a-hexahydro-1H-10-thia-dibenzo[a,d]cyclohepten-5-one

: 130953-92-3
N-((4aR,5R,11aR)-7-Chloro-1,2,3,4,4a,5,11,11a-octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-4-[4-(4-fluoro-phenyl)-piperazin-1-yl]-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / 5 h / 220 °C

2: 70 percent / 36percent HCl / ethanol / 0.5 h / Heating

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1021/jm00106a019

Reference yield:

: 130933-34-5
(6aR^*,10aR^*,11R^*)-2-chloro-11-(formylamino)-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin

: 130953-92-3
N-((4aR,5R,11aR)-7-Chloro-1,2,3,4,4a,5,11,11a-octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-4-[4-(4-fluoro-phenyl)-piperazin-1-yl]-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / 36percent HCl / ethanol / 0.5 h / Heating

2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1021/jm00106a019

Reference yield:

: 130933-88-9
ethyl 4-<4-(4-fluorophenyl)-1-piperazinyl>butyrate

: 130953-92-3
N-((4aR,5R,11aR)-7-Chloro-1,2,3,4,4a,5,11,11a-octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-4-[4-(4-fluoro-phenyl)-piperazin-1-yl]-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / 2 N NaOH / ethanol / 1 h / Ambient temperature

2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 1 h / Ambient temperature

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1021/jm00106a019