8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE

Base Information

• Chemical Name: 8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE
• CAS No.: 54346-33-7
• Molecular Formula: C6H4 Br Cl N4 S
• Molecular Weight: 279.548
• Hs Code.: 2933990090
• Mol file: 54346-33-7.mol

Synonyms:8-Bromo-4-chloro-2-(methylthio)pyrazolo[1,5-a]-1,3,5-triazine

Chemical Property of 8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE

Chemical Property:

• PSA: 68.38000
• Density: 2.109g/cm3
• LogP: 2.26210

Purity/Quality:

98%min ^*data from raw suppliers

8-Bromo-4-chloro-2-(methylthio)-pyrazolo[1,5-a][1,3,5]triazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE

There total 12 articles about 8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-chloro-2-methylthiopyrazolo(1,5-a)-1,3,5-triazine (54346-19-9) → 8-bromo-2-(methylthio)-4-chloropyrazolo<1,5-a>-1,3,5-triazine (54346-33-7)

Guidance literature:

With N-Bromosuccinimide; In chloroform; at 80 ℃; for 0.133333h; Sealed tube; Microwave irradiation;

DOI:10.3390/molecules26123540

Reference yield: 67.0%

8-bromo-2-(methylsulfanyl)pyrazolo[1,5-a][1,3,5]triazin-4-ol (54346-35-9) → 8-bromo-2-(methylthio)-4-chloropyrazolo<1,5-a>-1,3,5-triazine (54346-33-7)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-aniline; at 105 ℃; for 3h;

Reference yield: 67.0%

8-bromo-2-(methylsulfanyl)pyrazolo[1,5-a][1,3,5]triazin-4-ol (54346-35-9) + N,N-dimethyl-aniline (121-69-7,77733-26-7) → 8-bromo-2-(methylthio)-4-chloropyrazolo<1,5-a>-1,3,5-triazine (54346-33-7)

Guidance literature:

With trichlorophosphate; at 105 ℃; for 3h;

upstream raw materials:

ethyl N-[(1H-pyrazol-5-yl)carbamothioyl]carbamate

2-sulfanylidene-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one

2-(methylsulfanyl)-3H-pyrazolo[1,5-a][1,3,5]triazin-4-one

8-bromo-2-(methylsulfanyl)pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one

Downstream raw materials:

N-cyclopropyl-4-(2-(methylthio)-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide

2-chloro-N-cyclopropyl-4-(2-(methylthio)-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide

N-cyclopropyl-4-(4-((4-methoxybenzyl)(2-morpholinoethyl)amino)-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-8-yl)-2-methylbenzamide

Refernces

• 1、 -. "PYRAZOLOTRIAZINES". . . Retrieved 2021/06/22.
• 2、 -. "PYRAZOLOPYRAZINES ACTING ON CANCERS VIA INHIBITION OF CDK12". . . Retrieved 2021/09/11.