2-[4-(chloromethyl)phenyl]-1,3-thiazole

Base Information

• Chemical Name: 2-[4-(chloromethyl)phenyl]-1,3-thiazole
• CAS No.: 906352-61-2
• Molecular Formula: C10H8 Cl N S
• Molecular Weight: 209.69500
• Mol file: 906352-61-2.mol

Synonyms:

Chemical Property of 2-[4-(chloromethyl)phenyl]-1,3-thiazole

Chemical Property:

• PSA: 41.13000
• LogP: 3.54890

Purity/Quality:

98%min ^*data from raw suppliers

2-[4-(chloromethyl)phenyl]-1,3-thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[4-(chloromethyl)phenyl]-1,3-thiazole

There total 2 articles about 2-[4-(chloromethyl)phenyl]-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(4-(thiazol-2-yl)phenyl)methanol (454678-91-2) → 2[4-(chloromethyl)phenyl]-1,3-thiazole (906352-61-2)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c01372

Reference yield:

4-(thiazol-2-yl)-benzaldehyde (198904-53-9) → 2[4-(chloromethyl)phenyl]-1,3-thiazole (906352-61-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 0.5 h / 0 - 20 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; thionyl chloride; In ethanol; dichloromethane;

DOI:10.1021/acs.jmedchem.0c01372

Reference yield: 96.0%

2[4-(chloromethyl)phenyl]-1,3-thiazole (906352-61-2) + 1-(2-hydroxycyclohexyl)-4-(2-hydroxyphenyl)pyridin-2(1H)-one → 1-(2-hydroxycyclohexyl)-4-(2-((4-(thiazol-2-yl)benzyl)oxy)phenyl)pyridin-2(1H)-one

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/acs.jmedchem.5b01562

upstream raw materials:

4-(thiazol-2-yl)-benzaldehyde

(4-(thiazol-2-yl)phenyl)methanol

Downstream raw materials:

Triethyl 2-(4-(thiazol-2-yl)phenyl)ethane-1,1,1-tricarboxylate

Refernces