trans-2,3,3a,4,5,9b-hexahydro-7-methoxy-3aβ-methyl-3-(2-phenylsulphinylvinylidene)-1H-benzindene

Base Information

Chemical Name:trans-2,3,3a,4,5,9b-hexahydro-7-methoxy-3aβ-methyl-3-(2-phenylsulphinylvinylidene)-1H-benzindene
CAS No.:114683-40-8
Molecular Formula:C₂₃H₂₄O₂S
Molecular Weight:364.508
Hs Code.:

trans-2,3,3a,4,5,9b-hexahydro-7-methoxy-3aβ-methyl-3-(2-phenylsulphinylvinylidene)-1H-benz<e>indene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-2,3,3a,4,5,9b-hexahydro-7-methoxy-3aβ-methyl-3-(2-phenylsulphinylvinylidene)-1H-benzindene

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Technology Process of trans-2,3,3a,4,5,9b-hexahydro-7-methoxy-3aβ-methyl-3-(2-phenylsulphinylvinylidene)-1H-benzindene

There total 8 articles about trans-2,3,3a,4,5,9b-hexahydro-7-methoxy-3aβ-methyl-3-(2-phenylsulphinylvinylidene)-1H-benzindene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 4972-29-6
benzenesulphinyl chloride

: 960-28-1,1220-74-2,50395-36-3,98171-95-0
trans-3α-ethynyl-2,3,3a,4,5,9b-hexahydro-7-methoxy-3aβ-methyl-1H-benzinden-3β-ol

: 114683-40-8
trans-2,3,3a,4,5,9b-hexahydro-7-methoxy-3aβ-methyl-3-(2-phenylsulphinylvinylidene)-1H-benzindene

Guidance literature:: With triethylamine; In dichloromethane; 1.) , -78 deg C, 30 min, 2.) -40 deg C, 30 min;

Reference yield:

: 837-20-7,887-47-8,4273-50-1,75657-42-0,75657-43-1,80299-97-4,91423-20-0,95709-45-8,113667-60-0
trans-1,2,3a,4,5,9b-hexahydro-7-methoxy-3aβ-methylbenzinden-3-one

: 114683-40-8
trans-2,3,3a,4,5,9b-hexahydro-7-methoxy-3aβ-methyl-3-(2-phenylsulphinylvinylidene)-1H-benzindene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1.56 M n-butyl-lithium / 1.) THF, hexane, -78 deg C, 1 h; 2.) THF, hexane, -78 deg C, 2.5 h

2: tetra-n-butylammonium fluoride / tetrahydrofuran / 1.5 h / Ambient temperature

3: 56 percent / 1.) triethylamine / CH₂Cl₂ / 1.) , -78 deg C, 30 min, 2.) -40 deg C, 30 min

With n-butyllithium; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 77188-80-8
1-(4-methoxybenzocyclobutenyl)-4-methyl-4-penten-3-ol

: 114683-40-8
trans-2,3,3a,4,5,9b-hexahydro-7-methoxy-3aβ-methyl-3-(2-phenylsulphinylvinylidene)-1H-benzindene

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / pyridinium chlorochromate, Florisil / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) 1.6 M t-butyl-lithium / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, 30 min

3: 60 percent / 1,2-dichloro-benzene / 40 h / Heating

4: 1.) ozone; 2.) NaBH₄ / 1.) methanol, CH₂Cl₂, -78 deg C, 3 min; 2.) methanol, CH₂Cl₂, 45 min, RT

5: 93 percent / pyridine, lead tetra-acetate / benzene / 2 h / Ambient temperature

6: 1.) 1.56 M n-butyl-lithium / 1.) THF, hexane, -78 deg C, 1 h; 2.) THF, hexane, -78 deg C, 2.5 h

7: tetra-n-butylammonium fluoride / tetrahydrofuran / 1.5 h / Ambient temperature

8: 56 percent / 1.) triethylamine / CH₂Cl₂ / 1.) , -78 deg C, 30 min, 2.) -40 deg C, 30 min

With pyridine; lead(IV) acetate; sodium tetrahydroborate; florisil; n-butyllithium; tetrabutyl ammonium fluoride; tert.-butyl lithium; ozone; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; 1,2-dichloro-benzene; benzene;