N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide

Base Information

• Chemical Name: N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide
• CAS No.: 677338-12-4
• Molecular Formula: C₁₈H₁₇N₅O₃
• Molecular Weight: 351.365
• Mol file: 677338-12-4.mol

Synonyms:PIK 85;PIK90;

Chemical Property of N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide

Chemical Property:

• PKA: 9.52±0.20(Predicted)
• Density: 1.42 g/cm³
• Solubility.: insoluble in DMSO

Purity/Quality:

97% ^*data from raw suppliers

PIK-90 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: PIK-90 is a PI3Kα/γ/δ inhibitor with IC50 of 11 nM/18 nM/58 nM, respectively, less potent to PI3Kβ.
• Uses: PIK-90 is a PI3Kα/γ/δ inhibitor, less potent to PI3Kβ.

Technology Process of N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide

There total 2 articles about N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-(8-hydroxy-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide (1032570-81-2) + dimethyl sulfate (77-78-1) → PIK-90 (677338-12-4)

Guidance literature:

N-(8-hydroxy-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide; dimethyl sulfate; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

In methanol; dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/cmdc.201600148

Reference yield:

→ PIK-90 (677338-12-4)

Guidance literature:

upstream raw materials:

N-(8-hydroxy-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide

dimethyl sulfate