AS-252424

Base Information

Chemical Name:AS-252424
CAS No.:900515-16-4
Molecular Formula:C₁₄H₈FNO₄S
Molecular Weight:305.286
Hs Code.:
UNII:63D4RUV1GN
ChEMBL ID:CHEMBL379156
DSSTox Substance ID:DTXSID801017365
Wikidata:Q27263607
Mol file:900515-16-4.mol

Synonyms:5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione;AS 252424;AS-252424;AS252424

Suppliers and Price of AS-252424

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
AS 252424
10mg
$ 516.00

TRC
AS-252424
25mg
$ 360.00

Tocris
AS252424 ≥98%(HPLC)
10
$ 255.00

Sigma-Aldrich
AS-252424 ≥98% (HPLC), solid
5mg
$ 301.00

Sigma-Aldrich
AS-252424 ≥98% (HPLC), solid
25mg
$ 1110.00

Matrix Scientific
(E)-5-((5-(4-Fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione 97%
1g
$ 2250.00

Matrix Scientific
(E)-5-((5-(4-Fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione 97%
5g
$ 4500.00

DC Chemicals
AS-252424 >98%
100 mg
$ 500.00

Crysdot
AS-252424 98+%
5mg
$ 54.00

Crysdot
AS-252424 98+%
10mg
$ 98.00

Total 33 raw suppliers

Chemical Property of AS-252424

Chemical Property:

PSA：104.84000
Density:1.56 g/cm³
LogP:3.44400
Storage Temp.:2-8°C
Solubility.:DMSO: >20mg/mL
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:305.01580707
Heavy Atom Count:21
Complexity:484

Purity/Quality:

97% ^*data from raw suppliers

AS 252424 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)O)C2=CC=C(O2)C=C3C(=O)NC(=O)S3
Isomeric SMILES:C1=CC(=C(C=C1F)O)C2=CC=C(O2)/C=C\3/C(=O)NC(=O)S3
Uses AS-252424 is a novel, potent, and selective phosphoinositide 3-kinase gamma (PI3Kγ) inhibitor. It is also an inhibitor of Casein kinase and PI3K p110α.

Technology Process of AS-252424

There total 5 articles about AS-252424 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27329-70-0
5-formylfurane-2-boronic acid

: 900515-16-4
(5Z)-5-[[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine)palladium⁽⁰⁾; aq. potassium carbonate / ethanol; toluene / 4 h / Heating

2: 300 mg / BCl₃ / CH₂Cl₂ / 0.5 h / -70 °C

3: β-alanine; acetic acid / 1 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trichloride; potassium carbonate; acetic acid; 3-amino propanoic acid; In ethanol; dichloromethane; toluene; 1: Suzuki cross-coupling / 3: Knoevenagel reaction;
DOI:10.1021/jm0601598

Reference yield:

: 147460-41-1
2-bromo-5-fluorophenol

: 900515-16-4
(5Z)-5-[[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine)palladium⁽⁰⁾; aq. potassium carbonate / ethanol; toluene / 12 h / Heating

2: β-alanine; acetic acid / 1 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; 3-amino propanoic acid; In ethanol; toluene; 1: Suzuki cross-coupling / 2: Knoevenagel reaction;
DOI:10.1021/jm0601598

Reference yield:

: 202857-88-3
2-Benzyloxy-1-bromo-4-fluoro-benzene

: 900515-16-4
(5Z)-5-[[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine)palladium⁽⁰⁾; aq. potassium carbonate / ethanol; toluene / 4 h / Heating

2: 300 mg / BCl₃ / CH₂Cl₂ / 0.5 h / -70 °C

3: β-alanine; acetic acid / 1 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trichloride; potassium carbonate; acetic acid; 3-amino propanoic acid; In ethanol; dichloromethane; toluene; 1: Suzuki cross-coupling / 3: Knoevenagel reaction;
DOI:10.1021/jm0601598