Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxymethoxy)-5-[3-(2-methoxy-ethoxymethyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine

Base Information

• Chemical Name: Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxymethoxy)-5-[3-(2-methoxy-ethoxymethyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine
• CAS No.: 100190-49-6
• Molecular Formula: C₆H₁₅N*C₄₇H₅₁ClN₃O₁₅P
• Molecular Weight: 1065.55
• Mol file: 100190-49-6.mol

Synonyms:

Chemical Property of Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxymethoxy)-5-[3-(2-methoxy-ethoxymethyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxymethoxy)-5-[3-(2-methoxy-ethoxymethyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine

There total 5 articles about Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxymethoxy)-5-[3-(2-methoxy-ethoxymethyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

O-8-(5-chloroquinolyl) phosphate (71933-71-6) + 1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-methoxy-ethoxymethoxy)-tetrahydro-furan-2-yl]-3-(2-methoxy-ethoxymethyl)-1H-pyrimidine-2,4-dione (99328-73-1) + triethylamine (121-44-8) → Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxymethoxy)-5-[3-(2-methoxy-ethoxymethyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine (100190-49-6)

Guidance literature:

With pyridine; quinoline-8-sulfonyl chloride; for 2h; Ambient temperature;

DOI:10.1021/jo00356a033

Reference yield:

<(2-methoxyethoxy)methyl>triethylammonium chloride (60043-43-8) → Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxymethoxy)-5-[3-(2-methoxy-ethoxymethyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine (100190-49-6)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran / 16 h / Heating

2: 1 M tributylammonium fluoride (TBAHF) / tetrahydrofuran / 3 h / Ambient temperature

3: 95 percent / pyridine / 1 h

4: 88 percent / 8-quinolinesulfonyl chloride (QS-Cl), pyridine / 2 h / Ambient temperature

With pyridine; quinoline-8-sulfonyl chloride; tri-n-butylamine hydrofluoride; In tetrahydrofuran;

DOI:10.1021/jo00356a033

Reference yield:

3-(2-Methoxy-ethoxymethyl)-1-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(2-methoxy-ethoxymethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidine-2,4-dione (99328-69-5) → Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxymethoxy)-5-[3-(2-methoxy-ethoxymethyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine (100190-49-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1 M tributylammonium fluoride (TBAHF) / tetrahydrofuran / 3 h / Ambient temperature

2: 95 percent / pyridine / 1 h

3: 88 percent / 8-quinolinesulfonyl chloride (QS-Cl), pyridine / 2 h / Ambient temperature

With pyridine; quinoline-8-sulfonyl chloride; tri-n-butylamine hydrofluoride; In tetrahydrofuran;

DOI:10.1021/jo00356a033

upstream raw materials:

O-8-(5-chloroquinolyl) phosphate

1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-methoxy-ethoxymethoxy)-tetrahydro-furan-2-yl]-3-(2-methoxy-ethoxymethyl)-1H-pyrimidine-2,4-dione

triethylamine

<(2-methoxyethoxy)methyl>triethylammonium chloride

Downstream raw materials:

C₆₈H₈₅ClN₅O₂₆P

Refernces