2-Bromo-6-nitrobenzoic acid

Base Information

• Chemical Name: 2-Bromo-6-nitrobenzoic acid
• CAS No.: 38876-67-4
• Molecular Formula: C7H4BrNO4
• Molecular Weight: 246.017
• Hs Code.: 2916399090
• Mol file: 38876-67-4.mol

Synonyms:2-Bromo-6-nitrobenzoicacid;

Chemical Property of 2-Bromo-6-nitrobenzoic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 177-178 °C
• Refractive Index: 1.65
• Boiling Point: 365.286 °C at 760 mmHg
• PKA: pK1: 1.37 (25°C)
• Flash Point: 174.719 °C
• PSA: 83.12000
• Density: 1.893 g/cm³
• LogP: 2.57870
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-6-nitrobenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-6-nitrobenzoic acid

There total 5 articles about 2-Bromo-6-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

6-nitroanthranilic acid (50573-74-5) → 2-bromo-6-nitrobenzoic acid (38876-67-4)

Guidance literature:

6-nitroanthranilic acid; With hydrogen bromide; acetic acid; sodium nitrite; In water; at 0 ℃; Inert atmosphere;

With copper(I) bromide; In water; at 0 - 65 ℃; Inert atmosphere;

DOI:10.1021/jacs.5b00033

Reference yield: 40.0%

2-bromo-6-nitrotoluene (55289-35-5) → 2-bromo-6-nitrobenzoic acid (38876-67-4)

Guidance literature:

With potassium permanganate; sodium carbonate; In water; Heating;

Reference yield:

→ 2-bromo-6-nitrobenzoic acid (38876-67-4)

Guidance literature:

With copper(I) bromide; hydrogen bromide;

DOI:10.1021/ja01142a025

upstream raw materials:

2-bromo-6-nitrotoluene

2-carbamoyl-6-nitrobenzoic acid

6-nitroanthranilic acid

4-nitro-1H-isoindole-1,3(2H)-dione

Downstream raw materials:

2-amino-6-chlorobenzoic acid

2-amino-5-hydroxybenzoic acid

8-amino-2-methyl-3,4-dihydroisoquinolin-1-one

2-(2-methoxycarbonylamino-ethyl)-6-nitro-benzoic acid methylester

Refernces

• 1、 Glossop, Steve C.. "A microwave-assisted alternative synthesis of 8-amino-2-methyl-3,4- dihydroisoquinolin-1-one". . p. 981 - 983. Retrieved 2008/02/02.
• 2、 Hewson, Alan T.,Hughes, Kevin,Richardson, Steward K.,Sharpe, David A.,Wadsworth, Alan H.. "Acid-catalysed Cyclisation of o-Sulphonamido Ketene Dithioacetal S-Oxides: A Novel Synthesis of the Indole Ring System". . p. 1565 - 1569. Retrieved 2007/10/02.