2-Bromo-5-cyano-3-picoline

Base Information

• Chemical Name: 2-Bromo-5-cyano-3-picoline
• CAS No.: 374633-37-1
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.034
• Hs Code.: 2933399990
• Mol file: 374633-37-1.mol

Synonyms:6-Bromo-5-methylnicotinonitrile;3-pyridinecarbonitrile, 6-bromo-5-methyl-;6-Bromo-5-methylnicotinonitrile;

Chemical Property of 2-Bromo-5-cyano-3-picoline

Chemical Property:

• Boiling Point: 291.5 °C at 760 mmHg
• Flash Point: 130.1 °C
• PSA: 36.68000
• Density: 1.61 g/cm³
• LogP: 2.02418
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-5-cyano-3-picoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-5-cyano-3-picoline

There total 1 articles about 2-Bromo-5-cyano-3-picoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

P-toluenesulfonyl cyanide (19158-51-1) → 2-bromo-3-methyl-5-cyanopyridine (374633-37-1)

Guidance literature:

2,5-dibromo-3-methylpyridine; With n-butyllithium; In hexanes; diethyl ether; at -78 ℃; for 0.666667h;

P-toluenesulfonyl cyanide; In hexanes; diethyl ether; at -78 - 0 ℃;

Reference yield: 61.0%

2-bromo-3-methyl-5-cyanopyridine (374633-37-1) + (1S,5S,6S)-3-amino-5-(5-ethynyl-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide → (1S,5S,6S)-3-amino-5-(5-((5-cyano-3-methylpyridin-2-yl)ethynyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 60 ℃; for 1h; Inert atmosphere;

Reference yield: 44.0%

2-bromo-3-methyl-5-cyanopyridine (374633-37-1) + (E)-3-((1R,5S,6S)-3-amino-5-(5-ethynyl-2-fluorophenyl)-5-(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)-1-morpholinoprop-2-en-1-one → 6-((3-((1R,5S,6S)-3-amino-5-(fluoromethyl)-1-((E)-3-morpholino-3-oxoprop-1-en-1-yl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)-5-methylnicotinonitrile

Guidance literature:

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine; In tetrahydrofuran; at 60 ℃; for 2h; Inert atmosphere;

upstream raw materials:

P-toluenesulfonyl cyanide

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