Technology Process of (1R,2E)-1-(tri-n-butylstannyl)-1-{(benzyloxy)methoxy}-2-heptene
There total 2 articles about (1R,2E)-1-(tri-n-butylstannyl)-1-{(benzyloxy)methoxy}-2-heptene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
Hydroxy stannane was dissolved in CH2Cl2 and (i-Pr)2NEt was added, followed by of BOMCl, mixt. was stirred overnight (inert atm);; Mixt. was quenched with satd. aq. NH4Cl. aq. phase was extd. with ether, organic phases were dried over MgSO4, concd. and chromd. through silica gel; an ee>95%;;
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
To a soln. of hydroxy stannane in CH2Cl2 (i-Pr)2NEt was added, followed by MOMCl, mixt. was stirred for 8 h, (inert atm.);; Mixt. was quenched with satd. aq. NH4Cl, aq. phase was extd. with ether, organic phases were dried over MgSO4, chromd. slowly through silica gel (hexane); an ee .apprx. 77%;;
- Guidance literature:
-
With
boron trifluoride diethyl etherate;
In
dichloromethane;
Mixt. was stirred for 1 h at -78°C (inert atm.);; mixt. was quenched with satd. aq. NaHCO3 and warmed to room temp.; aq. phase was extd. with ether, organic phases were washed with brine, dried over anhyd. MgSO4, chromd. (hexane);;
