2-Amino-1-(3-chlorophenyl)ethanone hydrochloride

Base Information

• Chemical Name: 2-Amino-1-(3-chlorophenyl)ethanone hydrochloride
• CAS No.: 51084-83-4
• Molecular Formula: C8H8 Cl N O . Cl H
• Molecular Weight: 206.072
• Hs Code.: 2922399090
• European Community (EC) Number: 692-227-2
• DSSTox Substance ID: DTXSID00388592
• Mol file: 51084-83-4.mol

Synonyms:51084-83-4;2-amino-1-(3-chlorophenyl)ethanone hydrochloride;2-Amino-1-(3-chlorophenyl)ethan-1-one hydrochloride;2-Amino-3'-chloroacetophenone hydrochloride;2-Amino-1-(3-chloro-phenyl)-ethanone hydrochloride;2-amino-1-(3-chlorophenyl)ethanone;hydrochloride;NIOSH/AM5850000;3-chlorophenacylamine hydrochloride;2-Amino-3'-chloroacetophenone HCl;MFCD01673084;AM58500000;3-Chloro-omega-aminoacetophenone hydrochloride;Acetophenone, 2-amino-3'-chloro-, hydrochloride;606489-85-4;SCHEMBL2222643;DTXSID00388592;ORPJIXJTXWDVRY-UHFFFAOYSA-N;AMY27942;BCA08483;AKOS015890034;FS-6217;2-amino-1-(3-chlorophenyl)ethanone HCl;CS-0072068;FT-0652170;FT-0731618;C78269;EN300-729476;2-amino1-(3-chlorophenyl)ethanone hydrochloride;A828433;F2167-9283;Z1741966377

Chemical Property of 2-Amino-1-(3-chlorophenyl)ethanone hydrochloride

Chemical Property:

• Melting Point: 222 °C
• PSA: 43.09000
• LogP: 2.98370
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 205.0061193
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-1-(3-chlorophenyl)ethanoneHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)Cl)C(=O)CN.Cl

Technology Process of 2-Amino-1-(3-chlorophenyl)ethanone hydrochloride

There total 5 articles about 2-Amino-1-(3-chlorophenyl)ethanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ 2-amino-1-(3-chlorophenyl)ethanone hydrochloride (51084-83-4)

Guidance literature:

Reference yield: 93.0%

2-Amino-3-(3-chloro-phenyl)-3-oxo-propionic acid methyl ester; hydrochloride (93103-01-6) → 2-amino-1-(3-chlorophenyl)ethanone hydrochloride (51084-83-4)

Guidance literature:

With hydrogenchloride;

DOI:10.1248/cpb.32.2536

Reference yield: 21.0%

Br(1-)*C14H18ClN4O(1+) (1029539-01-2) → 2-amino-1-(3-chlorophenyl)ethanone hydrochloride (51084-83-4)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 0 - 50 ℃; for 3h;

upstream raw materials:

2-Amino-3-(3-chloro-phenyl)-3-oxo-propionic acid methyl ester; hydrochloride

Br^(1-)*C₁₄H₁₈ClN₄O⁽¹⁺⁾

2-bromo-1-(3-chloro-phenyl)-ethanone

3'-Chloroacetophenone

Downstream raw materials:

N-[2-(3-Chloro-phenyl)-2-oxo-ethyl]-2-[(Z)-2,4-dioxo-imidazolidin-1-ylimino]-acetamide

3-chloro-α-benzoylaminoacetophenone

C₁₉H₂₆ClN₃O₂S

C₁₉H₂₇ClN₂O₄S

Refernces

• 1、 Zhao, Liyu,Sun, Nannan,Tian, Linfeng,Sun, Yin,Chen, Yixuan,Wang, Xinran,Zhao, Shizhen,Su, Xin,Zhao, Dongmei,Cheng, Maosheng. "Combating fluconazole-resistant fungi with novel β-azole-phenylacetone derivatives". . . Retrieved 2019/09/19.
• 2、 -. "COMPOUND HAVING NPY Y5 RECEPTOR ANTAGONIST ACTIVITY". Page/Page column 41-42. . Retrieved 2011/02/25.