Chemical Property of Odanacatib
Chemical Property:
- Melting Point:223-224 °C
- Boiling Point:681.6±55.0 °C(Predicted)
- PKA:12.06±0.20(Predicted)
- PSA：107.44000
- Density:1.35 g/cm3
- LogP:6.49188
- Storage Temp.:Sealed in dry,Store in freezer, under -20°C
- Solubility.:Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly, Sonicated)
- XLogP3:4.1
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:9
- Rotatable Bond Count:9
- Exact Mass:525.17092555
- Heavy Atom Count:36
- Complexity:934
- Purity/Quality:
-
99%, *data from raw suppliers
MK-0822 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(C)(CC(C(=O)NC1(CC1)C#N)NC(C2=CC=C(C=C2)C3=CC=C(C=C3)S(=O)(=O)C)C(F)(F)F)F
- Isomeric SMILES:CC(C)(C[C@@H](C(=O)NC1(CC1)C#N)N[C@@H](C2=CC=C(C=C2)C3=CC=C(C=C3)S(=O)(=O)C)C(F)(F)F)F
- Recent ClinicalTrials:A Study of MK-0822 in Postmenopausal Women With Osteoporosis to Assess Fracture Risk (MK-0822-018)
- Recent EU Clinical Trials:An Open-Label 5-Year 2nd Extension to: A Phase III Randomized, Placebo-Controlled
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Uses
MK-0822 is a newly developed bone-targeting dual action pro-drug for osteoporosis and bone metastasis. It is also an inhibitor of cathepsin K, an enzyme involved in bone resorption.
