3-(R)-AMINO-PIPERIDIN-2-ONE HYDROCHLORIDE

Base Information

• Chemical Name: 3-(R)-AMINO-PIPERIDIN-2-ONE HYDROCHLORIDE
• CAS No.: 406216-02-2
• Molecular Formula: C₅H₁₀N₂O*(x)ClH
• Molecular Weight: 150.61
• Mol file: 406216-02-2.mol

Synonyms:2-Piperidinone,3-amino-, monohydrochloride, (3R)- (9CI)

Chemical Property of 3-(R)-AMINO-PIPERIDIN-2-ONE HYDROCHLORIDE

Chemical Property:

• PSA: 55.12000
• LogP: 1.05480
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(R)-3-Aminopiperidin-2-one hydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(R)-AMINO-PIPERIDIN-2-ONE HYDROCHLORIDE

There total 6 articles about 3-(R)-AMINO-PIPERIDIN-2-ONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3(S)-<(butoxycarbonyl)amino>-2-oxopiperidine (92235-39-7) → (3S)-3-aminopiperidin-2-one hydrochloride (42538-31-8,406216-02-2)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃; for 1h;

DOI:10.1021/jm00402a031

Reference yield: 97.0%

L-ornithine hydrochloride (3184-13-2,36630-89-4) → (3S)-3-aminopiperidin-2-one hydrochloride (42538-31-8,406216-02-2)

Guidance literature:

L-ornithine hydrochloride; With chloro-trimethyl-silane; In methanol; at 20 ℃; for 12h; under 760.051 Torr;

With sodium ethanolate; In methanol; ethanol; at 0 - 20 ℃; for 0.583333h; under 760.051 Torr; enantioselective reaction;

DOI:10.3762/bjoc.13.27

Reference yield: 60.0%

methyl (S)-2,5-diaminopentanoate dihydrochloride (40216-82-8,60080-69-5) → (3S)-3-aminopiperidin-2-one hydrochloride (42538-31-8,406216-02-2)

Guidance literature:

With sodium methylate; In methanol;

DOI:10.1039/DT9870001127

upstream raw materials:

methyl (S)-2,5-diaminopentanoate dihydrochloride

3(S)-<(butoxycarbonyl)amino>-2-oxopiperidine

L-ornithine hydrochloride

methyl (S)-5-(((benzyloxy)carbonyl)amino)-2-((tertbutoxycarbonyl)amino)pentanoate

Downstream raw materials:

(S)-3-[[(phenylmethoxy)carbonyl]amino]-2-oxopiperidine

(+/-)-3-<(tert-butoxycarbonyl)amino>-2-piperidone

(S)-piperidin-3-amine

Refernces

• 1、 Barnett, Robert,Raszkowski, Daniel,Winckler, Thomas,Stallforth, Pierre. "Versatile synthesis of the signaling peptide glorin". supporting information. p. 247 - 250. Retrieved 2017/03/14.
• 2、 -. "NEW HETEROCYCLIC AMIDE COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM". Page 85. . Retrieved 2010/11/30.