C₅₀H₅₂BrN₅O₁₃

Base Information

• Chemical Name: C₅₀H₅₂BrN₅O₁₃
• CAS No.: 90044-45-4
• Molecular Formula: C₅₀H₅₂BrN₅O₁₃
• Molecular Weight: 1010.89
• Mol file: 90044-45-4.mol

Synonyms:

Chemical Property of C₅₀H₅₂BrN₅O₁₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₀H₅₂BrN₅O₁₃

There total 29 articles about C₅₀H₅₂BrN₅O₁₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromoisatin (6326-79-0) → C50H52BrN5O13 (90044-45-4,94841-56-2)

Guidance literature:

Multi-step reaction with 15 steps

1: 82 percent / piperidine, acetic acid / benzene / 5 h / Heating

2: 92 percent / Na₂S₂O₄ / ethanol; H₂O / 0.08 h / Heating

3: 27 percent / NH₂NH₂*H₂O / CH₂Cl₂; methanol / 0.5 h

4: 90 percent / NaHCO₃ / dimethylformamide / 1 h / Ambient temperature

5: 94 percent / Zn, AcOH / tetrahydrofuran / 10 h / 0 °C

6: 50 percent / pyridine / 2 h / 70 °C

7: 14 percent / NaBH₃CN, 2N aq. HCl / ethyl acetate / 0.17 h

8: 92 percent / benzene / 5 h / Ambient temperature

9: 83 percent / pyridine / Ambient temperature

10: 77 percent / Ac₂O / 2 h / 120 °C

11: 96 percent / 80percent m-CPBA / CH₂Cl₂ / 0.5 h / 0 - 25 °C

12: 82 percent / 0.1 M aq. NaHCO₃-Na₂CO₃ / acetone / 1 h / Ambient temperature; pH 10.2

13: 28 percent / picryl chloride / pyridine / 1.5 h / Ambient temperature

14: 72 percent / 0.1 N KOH / methanol / 2 h / Ambient temperature

15: 1.) Pb(OAc)4, 2.) NaBH₃CN / 1.) AcOH, room temp., 15 min, 2.) AcOH, room temp., 20 min

With piperidine; pyridine; lead(IV) acetate; hydrogenchloride; potassium hydroxide; sodium dithionite; 2,4,6-trinitrochlorobenzene; acetic anhydride; sodium cyanoborohydride; sodium hydrogencarbonate; sodium carbonate; hydrazine hydrate; acetic acid; 3-chloro-benzenecarboperoxoic acid; zinc; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; benzene;

DOI:10.1016/S0040-4020(01)86989-1

Reference yield:

2-(methylthio)ethyl 6-bromo-α-<(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl>-2,3-dihydro-2-oxo-1H-indole-3-acetate (94779-72-3) → C50H52BrN5O13 (90044-45-4,94841-56-2)

Guidance literature:

Multi-step reaction with 13 steps

1: 27 percent / NH₂NH₂*H₂O / CH₂Cl₂; methanol / 0.5 h

2: 90 percent / NaHCO₃ / dimethylformamide / 1 h / Ambient temperature

3: 94 percent / Zn, AcOH / tetrahydrofuran / 10 h / 0 °C

4: 50 percent / pyridine / 2 h / 70 °C

5: 14 percent / NaBH₃CN, 2N aq. HCl / ethyl acetate / 0.17 h

6: 92 percent / benzene / 5 h / Ambient temperature

7: 83 percent / pyridine / Ambient temperature

8: 77 percent / Ac₂O / 2 h / 120 °C

9: 96 percent / 80percent m-CPBA / CH₂Cl₂ / 0.5 h / 0 - 25 °C

10: 82 percent / 0.1 M aq. NaHCO₃-Na₂CO₃ / acetone / 1 h / Ambient temperature; pH 10.2

11: 28 percent / picryl chloride / pyridine / 1.5 h / Ambient temperature

12: 72 percent / 0.1 N KOH / methanol / 2 h / Ambient temperature

13: 1.) Pb(OAc)4, 2.) NaBH₃CN / 1.) AcOH, room temp., 15 min, 2.) AcOH, room temp., 20 min

With pyridine; lead(IV) acetate; hydrogenchloride; potassium hydroxide; 2,4,6-trinitrochlorobenzene; acetic anhydride; sodium cyanoborohydride; sodium hydrogencarbonate; sodium carbonate; hydrazine hydrate; acetic acid; 3-chloro-benzenecarboperoxoic acid; zinc; In tetrahydrofuran; pyridine; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; benzene;

DOI:10.1016/S0040-4020(01)86989-1

Reference yield:

(8-Acetyl-2,4-bis-benzyloxy-7,8-dihydro-pteridin-6-yl)-[1-acetyl-6-bromo-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid 2-methylsulfanyl-ethyl ester (94779-76-7,94779-77-8) → C50H52BrN5O13 (90044-45-4,94841-56-2)

Guidance literature:

Multi-step reaction with 9 steps

1: 14 percent / NaBH₃CN, 2N aq. HCl / ethyl acetate / 0.17 h

2: 92 percent / benzene / 5 h / Ambient temperature

3: 83 percent / pyridine / Ambient temperature

4: 77 percent / Ac₂O / 2 h / 120 °C

5: 96 percent / 80percent m-CPBA / CH₂Cl₂ / 0.5 h / 0 - 25 °C

6: 82 percent / 0.1 M aq. NaHCO₃-Na₂CO₃ / acetone / 1 h / Ambient temperature; pH 10.2

7: 28 percent / picryl chloride / pyridine / 1.5 h / Ambient temperature

8: 72 percent / 0.1 N KOH / methanol / 2 h / Ambient temperature

9: 1.) Pb(OAc)4, 2.) NaBH₃CN / 1.) AcOH, room temp., 15 min, 2.) AcOH, room temp., 20 min

With lead(IV) acetate; hydrogenchloride; potassium hydroxide; 2,4,6-trinitrochlorobenzene; acetic anhydride; sodium cyanoborohydride; sodium hydrogencarbonate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In pyridine; methanol; dichloromethane; ethyl acetate; acetone; benzene;

DOI:10.1016/S0040-4020(01)86989-1

upstream raw materials:

C₅₀H₅₂BrN₅O₁₃

6-bromoisatin

2-(methylthio)ethyl 6-bromo-α-<(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl>-2,3-dihydro-2-oxo-1H-indole-3-acetate

2-(methylthio)ethyl α-(aminoacetyl)-6-bromo-2,3-dihydro-2-oxo-1H-indole-3-acetate hydrochloride

Downstream raw materials:

C₂₅H₂₄BrN₅O₁₂

(+/-)-surugatoxin