N-(8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-2-yl)-2-phenoxy-acetamide

Base Information

• Chemical Name: N-(8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-2-yl)-2-phenoxy-acetamide
• CAS No.: 896719-75-8
• Molecular Formula: C₆₆H₅₉N₉O₈
• Molecular Weight: 1106.25
• Mol file: 896719-75-8.mol

Synonyms:

Chemical Property of N-(8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-2-yl)-2-phenoxy-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-2-yl)-2-phenoxy-acetamide

There total 4 articles about N-(8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-2-yl)-2-phenoxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C70H81N9O6Si2 (896719-71-4) → N-(8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-2-yl)-2-phenoxy-acetamide (896719-75-8)

Guidance literature:

Multi-step reaction with 4 steps

1: trichloroacetic acid / CH₂Cl₂; methanol

2: pyridine / 0 °C

3: triethylamine trihydrogenfluoride complex / tetrahydrofuran / 24 h

4: lutidine / 20 °C

With pyridine; lutidine; triethylamine tris(hydrogen fluoride); trichloroacetic acid; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/tx050296s

Reference yield:

N8-benzyl-6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine (896719-72-5) → N-(8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-2-yl)-2-phenoxy-acetamide (896719-75-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 0 °C

2: triethylamine trihydrogenfluoride complex / tetrahydrofuran / 24 h

3: lutidine / 20 °C

With pyridine; lutidine; triethylamine tris(hydrogen fluoride); In tetrahydrofuran;

DOI:10.1021/tx050296s

Reference yield:

N-{8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-yl}-2-phenoxy-acetamide (896719-73-6) → N-(8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-2-yl)-2-phenoxy-acetamide (896719-75-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine trihydrogenfluoride complex / tetrahydrofuran / 24 h

2: lutidine / 20 °C

With lutidine; triethylamine tris(hydrogen fluoride); In tetrahydrofuran;

DOI:10.1021/tx050296s

upstream raw materials:

N-(O⁶-benzyl-N²-phenoxyacetyl-2'-deoxyguanosin-8-yl)-N-benzyl-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

N⁸-benzyl-6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N⁸-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine

N-{8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-yl}-2-phenoxy-acetamide

C₇₀H₈₁N₉O₆Si₂