3-(1-{2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-propyl}-3-ethyl-6-oxo-piperidin-3-yl)-propionic acid methyl ester

Base Information

• Chemical Name: 3-(1-{2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-propyl}-3-ethyl-6-oxo-piperidin-3-yl)-propionic acid methyl ester
• CAS No.: 132871-65-9
• Molecular Formula: C₂₈H₄₃F₃N₂O₅Si
• Molecular Weight: 572.741

Synonyms:

Chemical Property of 3-(1-{2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-propyl}-3-ethyl-6-oxo-piperidin-3-yl)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(1-{2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-propyl}-3-ethyl-6-oxo-piperidin-3-yl)-propionic acid methyl ester

There total 7 articles about 3-(1-{2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-propyl}-3-ethyl-6-oxo-piperidin-3-yl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-allyl-N-phenylamine (589-09-3) → 3-(1-{2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-propyl}-3-ethyl-6-oxo-piperidin-3-yl)-propionic acid methyl ester (132871-65-9,132871-70-6)

Guidance literature:

Multi-step reaction with 7 steps

1: Aza-Claisen reaction

2: Na₂CO₃ / diethyl ether

3: MCPBA, Na₂CO₃ / CH₂Cl₂

4: NaN₃, NH₄Cl / H₂O; acetonitrile

5: 100 percent / imidazole / dimethylformamide / 60 °C

6: PPh₃ / tetrahydrofuran / Heating

7: NaBH₄

With 1H-imidazole; sodium tetrahydroborate; sodium azide; sodium carbonate; ammonium chloride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(00)97229-0

Reference yield:

2-allyl-phenylamine (32704-22-6) → 3-(1-{2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-propyl}-3-ethyl-6-oxo-piperidin-3-yl)-propionic acid methyl ester (132871-65-9,132871-70-6)

Guidance literature:

Multi-step reaction with 6 steps

1: Na₂CO₃ / diethyl ether

2: MCPBA, Na₂CO₃ / CH₂Cl₂

3: NaN₃, NH₄Cl / H₂O; acetonitrile

4: 100 percent / imidazole / dimethylformamide / 60 °C

5: PPh₃ / tetrahydrofuran / Heating

6: NaBH₄

With 1H-imidazole; sodium tetrahydroborate; sodium azide; sodium carbonate; ammonium chloride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(00)97229-0

Reference yield:

N-(2-allylphenyl)-2,2,2-trifluoroacetamide (463932-04-9) → 3-(1-{2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-propyl}-3-ethyl-6-oxo-piperidin-3-yl)-propionic acid methyl ester (132871-65-9,132871-70-6)

Guidance literature:

Multi-step reaction with 5 steps

1: MCPBA, Na₂CO₃ / CH₂Cl₂

2: NaN₃, NH₄Cl / H₂O; acetonitrile

3: 100 percent / imidazole / dimethylformamide / 60 °C

4: PPh₃ / tetrahydrofuran / Heating

5: NaBH₄

With 1H-imidazole; sodium tetrahydroborate; sodium azide; sodium carbonate; ammonium chloride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(00)97229-0

upstream raw materials:

N-allyl-N-phenylamine

2-allyl-phenylamine

N-(2-allylphenyl)-2,2,2-trifluoroacetamide

N-[2-(3-Azido-2-hydroxy-propyl)-phenyl]-2,2,2-trifluoro-acetamide

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