(R)-2'-{3-ethyl-1-trifluoromethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide

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Chemical Name:(R)-2'-{3-ethyl-1-trifluoromethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide
CAS No.:1036401-77-0
Molecular Formula:C₂₇H₂₈F₆N₄O
Molecular Weight:538.536
Hs Code.:

(R)-2'-{3-ethyl-1-trifluoromethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide

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Chemical Property of (R)-2'-{3-ethyl-1-trifluoromethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide

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Technology Process of (R)-2'-{3-ethyl-1-trifluoromethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide

There total 11 articles about (R)-2'-{3-ethyl-1-trifluoromethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1036396-72-1
2-(2-ethyl-4-iodo-imidazol-1-yl)-ethylamine

: 1036401-77-0
(R)-2'-{3-ethyl-1-trifluoromethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 0.17 h / 140 °C / 4500.45 Torr / Microwave irradiation

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: copper(l) iodide; N,N,N,N,N,N-hexamethylphosphoric triamide / N,N-dimethyl-formamide / 80 °C

4: hydrogenchloride / 1,4-dioxane; dichloromethane / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / 80 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: |Pictet-Spengler Synthesis;
DOI:10.1016/j.bmcl.2013.01.088

Reference yield:

: 1036397-19-9
3-ethyl-1-iodo-8-[2-(4-trifluoromethyl-phenyl)-ethyl]-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine

: 1036401-77-0
(R)-2'-{3-ethyl-1-trifluoromethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: copper(l) iodide; N,N,N,N,N,N-hexamethylphosphoric triamide / N,N-dimethyl-formamide / 80 °C

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine / 80 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.01.088

Reference yield:

: 1036397-17-7
3-ethyl-1-iodo-8-[2-(4-trifluoromethyl-phenyl)-ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester

: 1036401-77-0
(R)-2'-{3-ethyl-1-trifluoromethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; N,N,N,N,N,N-hexamethylphosphoric triamide / N,N-dimethyl-formamide / 80 °C

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / 80 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.01.088