Carbamicacid, [6-(1,3-dioxan-2-yl)-4-oxohexyl]methyl-, phenylmethyl ester (9CI)

Base Information

Chemical Name:Carbamicacid, [6-(1,3-dioxan-2-yl)-4-oxohexyl]methyl-, phenylmethyl ester (9CI)
CAS No.:868618-72-8
Molecular Formula:C19H27 N O5
Molecular Weight:349.42100
Hs Code.:

Synonyms:benzyl [1(1S,2S)]-1-(1-phenyl-ethyl)-azetidine-2-carboxylate;Acetic acid,[(4-nitrophenyl)sulfonyl]-,phenylmethyl ester;benzyl [(4-nitrophenyl)sulfonyl]acetate;

Suppliers and Price of Carbamicacid, [6-(1,3-dioxan-2-yl)-4-oxohexyl]methyl-, phenylmethyl ester (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Carbamicacid, [6-(1,3-dioxan-2-yl)-4-oxohexyl]methyl-, phenylmethyl ester (9CI)

Chemical Property:

Boiling Point:496.0±40.0 °C(Predicted)
PSA：65.07000
Density:1.126±0.06 g/cm3(Predicted)
LogP:3.14750

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamicacid, [6-(1,3-dioxan-2-yl)-4-oxohexyl]methyl-, phenylmethyl ester (9CI)

There total 3 articles about Carbamicacid, [6-(1,3-dioxan-2-yl)-4-oxohexyl]methyl-, phenylmethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 33884-43-4
2-(2-Bromoethyl)-1,3-dioxane

: 868618-71-7
benzyl {4-[methoxy(methyl)amino]-4-oxobutyl}methylcarbamate

: 868618-72-8
benzyl [6-(1,3-dioxan-2-yl)-4-oxohexyl]methylcarbamate

Guidance literature:: 2-(2-Bromoethyl)-1,3-dioxane; With iodine; magnesium; In tetrahydrofuran; at 65 ℃;

benzyl {4-[methoxy(methyl)amino]-4-oxobutyl}methylcarbamate; In tetrahydrofuran; at 4 - 65 ℃; for 2h;
DOI:10.1021/op100251q

Reference yield:

: 1477840-37-1
C₆H₁₁BrMgO₂

: 868618-71-7
benzyl {4-[methoxy(methyl)amino]-4-oxobutyl}methylcarbamate

: 868618-72-8
benzyl [6-(1,3-dioxan-2-yl)-4-oxohexyl]methylcarbamate

Guidance literature:: C₆H₁₁BrMgO₂; benzyl {4-[methoxy(methyl)amino]-4-oxobutyl}methylcarbamate; In tetrahydrofuran; at 4 ℃; for 2h; Heating / reflux;

With water; citric acid; In tetrahydrofuran;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 868618-72-8
benzyl [6-(1,3-dioxan-2-yl)-4-oxohexyl]methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / water; toluene / 2 h

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h

2.2: 16 h

3.1: iodine; magnesium / tetrahydrofuran / 65 °C

3.2: 2 h / 4 - 65 °C

With iodine; magnesium; 1,1'-carbonyldiimidazole; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/op100251q