C₃₂H₃₃N₃O₈

Base Information

• Chemical Name: C₃₂H₃₃N₃O₈
• CAS No.: 1291095-91-4
• Molecular Formula: C₃₂H₃₃N₃O₈
• Molecular Weight: 587.629
• Mol file: 1291095-91-4.mol

Synonyms:

Chemical Property of C₃₂H₃₃N₃O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₃₃N₃O₈

There total 6 articles about C₃₂H₃₃N₃O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C11H15N3O6 (1291095-87-8) + 4,4'-dimethoxytrityl chloride (40615-36-9) → C32H33N3O8 (1291095-91-4)

Guidance literature:

With pyridine; for 14h; Inert atmosphere; Molecular sieve;

DOI:10.1021/ja111304f

Reference yield:

2'-deoxyuridine (951-78-0,63844-76-8) → C32H33N3O8 (1291095-91-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: pyridine; 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 24 h / Inert atmosphere

4.1: tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

5.1: pyridine; pyridine hydrogenfluoride / dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: pyridine / 14 h / Inert atmosphere; Molecular sieve

With pyridine; 1H-imidazole; hydroxylamine hydrochloride; sodium hydride; pyridine hydrogenfluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ja111304f

Reference yield:

3',5'-O-di(tert-butyldimethylsilyl)-2'-deoxyuridine (64911-18-8) → C32H33N3O8 (1291095-91-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 24 h / Inert atmosphere

3.1: tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

4.1: pyridine; pyridine hydrogenfluoride / dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: pyridine / 14 h / Inert atmosphere; Molecular sieve

With pyridine; hydroxylamine hydrochloride; sodium hydride; pyridine hydrogenfluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ja111304f

upstream raw materials:

C₂₁H₄₁N₃O₅Si₂

C₂₃H₄₃N₃O₆Si₂

C₁₁H₁₅N₃O₆

4,4'-dimethoxytrityl chloride

Downstream raw materials:

C₄₁H₅₀N₅O₉P