Technology Process of Nα,Nε-di-Z-L-lysyl-glycyl-Nε-Z-L-lysine methyl ester
There total 4 articles about Nα,Nε-di-Z-L-lysyl-glycyl-Nε-Z-L-lysine methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) dicyclohexylcarbodiimide / DMF-chloroform, 1.) -12 deg C, 10 min, 2.) -10 deg C, 40 min, 0 deg C, 1 h, then room temperature, 1 day
2: 80 percent / HCl / methanol; ethanol / 24 h / Ambient temperature
3: 1.) triethylamine / chloroform, 1.) 20 min, 2.) -12 deg C, 1 h, 0 deg C, 3 h, then room temperature, 3 h
With
hydrogenchloride; triethylamine; dicyclohexyl-carbodiimide;
In
methanol; ethanol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: HCl, NaNO2 / H2O; acetic acid / 0.17 h / -10 - -5 °C
2: 1.) triethylamine / chloroform, 1.) 20 min, 2.) -12 deg C, 1 h, 0 deg C, 3 h, then room temperature, 3 h
With
hydrogenchloride; triethylamine; sodium nitrite;
In
water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 80 percent / HCl / methanol; ethanol / 24 h / Ambient temperature
2: 1.) triethylamine / chloroform, 1.) 20 min, 2.) -12 deg C, 1 h, 0 deg C, 3 h, then room temperature, 3 h
With
hydrogenchloride; triethylamine;
In
methanol; ethanol;