3-[3-(Trifluoromethyl)phenoxy]azetidine

Base Information

• Chemical Name: 3-[3-(Trifluoromethyl)phenoxy]azetidine
• CAS No.: 76263-23-5
• Molecular Formula: C10H10F3NO
• Molecular Weight: 217.191
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60456620
• Wikidata: Q72512217
• Mol file: 76263-23-5.mol

Synonyms:76263-23-5;3-[3-(trifluoromethyl)phenoxy]azetidine;3-(3-(Trifluoromethyl)phenoxy)azetidine;3-(3-Trifluoromethyl-phenoxy)-azetidine;3-(3-Trifluoromethylphenoxy)azetidine;3-[3-(trifluoromethyl)phenoxy)azetidine;SCHEMBL83664;DTXSID60456620;AKOS012080832;3-(3-trifluoromethylphenoxy) azetidine;3-(3-Trifluoromethylphenoxy)-azetidine;SB38636;3-[3-(trifluoromethyl) phenoxy]azetidine;3-[3-(trifluoromethyl)-phenoxy]azetidine;LS-193318;CS-0054341;FT-0651322;4-(METHYLAMINO)BUTYRICACIDHYDROCHLORIDE;A25694;EN300-1936431;A1-12510

Chemical Property of 3-[3-(Trifluoromethyl)phenoxy]azetidine

Chemical Property:

• Vapor Pressure: 0.02mmHg at 25°C
• Refractive Index: 1.482
• Boiling Point: 251.816 °C at 760 mmHg
• Flash Point: 106.095 °C
• PSA: 21.26000
• Density: 1.278 g/cm³
• LogP: 3.18680
• Storage Temp.: 2-8°C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 217.07144843
• Heavy Atom Count: 15
• Complexity: 215

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-[3-(Trifluoromethyl)phenoxy]azetidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(CN1)OC2=CC=CC(=C2)C(F)(F)F

Technology Process of 3-[3-(Trifluoromethyl)phenoxy]azetidine

There total 3 articles about 3-[3-(Trifluoromethyl)phenoxy]azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(Diphenylmethyl)-3-[3-(trifluoromethyl)phenoxy] azetidine → 3-[3-(trifluoromethyl)phenoxy]azetidine (76263-23-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In acetic acid; at 20 ℃; for 3h;

Reference yield:

3-[3-(trifluoromethyl)phenoxy]azetidine hydrochloride → 3-[3-(trifluoromethyl)phenoxy]azetidine (76263-23-5)

Guidance literature:

With sodium carbonate; In acetonitrile; at 20 ℃; for 2h;

Reference yield:

→ 3-[3-(trifluoromethyl)phenoxy]azetidine (76263-23-5)

Guidance literature:

Downstream raw materials:

3-[3-(trifluoromethyl)phenoxy]-1-azetidinecarboxamide

N-methyl-3-[3-(trifluoromethyl)phenoxy]-1-azetidinecarboxamide

N-[3-(Diethylamino)propyl]-3-[3-(trifluoromethyl) phenoxy]-1-azetidinecarbothioamide, oxalate

Refernces

• 1、 -. "PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS". Paragraph 0441-0442. . Retrieved 2013/10/08.
• 2、 -. "Substituted phenyl methanone derivatives". Page/Page column 19. . Retrieved 2008/06/13.