2-(2,4-Difluorophenyl)pyrrolidine

Base Information

• Chemical Name: 2-(2,4-Difluorophenyl)pyrrolidine
• CAS No.: 524674-05-3
• Molecular Formula: C₁₀H₁₁F₂N
• Molecular Weight: 183.201
• DSSTox Substance ID: DTXSID70408433
• Mol file: 524674-05-3.mol

Synonyms:2-(2,4-difluorophenyl)pyrrolidine;524674-05-3;SCHEMBL3333995;DTXSID70408433;MFCD05189268;AKOS000152510;AKOS016343639;SY253337;BB 0249542;CS-0453270;FT-0751125;EN300-50506;A26450;N10911

Chemical Property of 2-(2,4-Difluorophenyl)pyrrolidine

Chemical Property:

• Boiling Point: 211.5 °C at 760 mmHg
• Flash Point: 81.7 °C
• PSA: 12.03000
• Density: 1.164 g/cm³
• LogP: 2.71810
• Storage Temp.: 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 183.08595568
• Heavy Atom Count: 13
• Complexity: 174

Purity/Quality:

99% ^*data from raw suppliers

2-(2,4-Difluorophenyl)pyrrolidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(NC1)C2=C(C=C(C=C2)F)F

Technology Process of 2-(2,4-Difluorophenyl)pyrrolidine

There total 2 articles about 2-(2,4-Difluorophenyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H23F2NO3S → 2-(2,4-difluorophenyl)pyrrolidine (1228569-91-2,524674-05-3)

Guidance literature:

With platinum(IV) oxide; hydrogen; trifluoroacetic acid; In ethanol; water; at 20 ℃; for 22h; under 760.051 Torr;

Reference yield:

N-[(2,4-difluorophenyl)methylidene]-(2S)-2-methylpropane-2-sulphinamide → 2-(2,4-difluorophenyl)pyrrolidine (1228569-91-2,524674-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane; tetrahydrofuran / 0.33 h / -60 °C

2: hydrogen; platinum(IV) oxide; trifluoroacetic acid / ethanol; water / 22 h / 20 °C / 760.05 Torr

With platinum(IV) oxide; hydrogen; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;

Refernces