(7R,12R,13R)-(E,E)-methyl 12-<(R)-α-methoxyphenylacetoxy>-14-methoxy-13-(methoxycarbonyl)-3,5,7-trimethyl-2,4-tetradecadienoate

Base Information

• Chemical Name: (7R,12R,13R)-(E,E)-methyl 12-<(R)-α-methoxyphenylacetoxy>-14-methoxy-13-(methoxycarbonyl)-3,5,7-trimethyl-2,4-tetradecadienoate
• CAS No.: 116052-68-7
• Molecular Formula: C₃₀H₄₄O₈
• Molecular Weight: 532.675
• Mol file: 116052-68-7.mol

Synonyms:

Chemical Property of (7R,12R,13R)-(E,E)-methyl 12-<(R)-α-methoxyphenylacetoxy>-14-methoxy-13-(methoxycarbonyl)-3,5,7-trimethyl-2,4-tetradecadienoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (7R,12R,13R)-(E,E)-methyl 12-<(R)-α-methoxyphenylacetoxy>-14-methoxy-13-(methoxycarbonyl)-3,5,7-trimethyl-2,4-tetradecadienoate

There total 2 articles about (7R,12R,13R)-(E,E)-methyl 12-<(R)-α-methoxyphenylacetoxy>-14-methoxy-13-(methoxycarbonyl)-3,5,7-trimethyl-2,4-tetradecadienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

(R)-methoxyphenylacetic acid (3966-32-3) + (7R,12R,13R)-(E,E)-methyl 12-hydroxy-14-methoxy-13-(methoxycarbonyl)-3,5,7-trimethyl-2,4-tetradecadienoate (116052-67-6) → (7R,12R,13R)-(E,E)-methyl 12-<(R)-α-methoxyphenylacetoxy>-14-methoxy-13-(methoxycarbonyl)-3,5,7-trimethyl-2,4-tetradecadienoate (116052-68-7) + (7R,12R,13R)-(E,E)-methyl 12-<(S)-α-methoxyphenylacetoxy>-14-methoxy-13-(methoxycarbonyl)-3,5,7-trimethyl-2,4-tetradecadienoate (116127-08-3)

Guidance literature:

With dmap; 2`,3`-dideoxycytidine; In dichloromethane; for 17h; Ambient temperature;

DOI:10.1021/jo00254a042

Reference yield:

(2'R,3'R,7R)-(E,E)-methyl 11-<3'-(hydroxymethyl)-4'-oxo-2'-oxethanyl>-3,5,7-trimethyl-2,4-undecadienoate (112830-96-3) → (7R,12R,13R)-(E,E)-methyl 12-<(R)-α-methoxyphenylacetoxy>-14-methoxy-13-(methoxycarbonyl)-3,5,7-trimethyl-2,4-tetradecadienoate (116052-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / CH₃ONa / 0.33 h / Ambient temperature

2: 91 percent / DDC, 4-(dimethylamino)pyridine / CH₂Cl₂ / 17 h / Ambient temperature

With dmap; sodium methylate; 2`,3`-dideoxycytidine; In dichloromethane;

DOI:10.1021/jo00254a042

upstream raw materials:

(R)-methoxyphenylacetic acid

(7R,12R,13R)-(E,E)-methyl 12-hydroxy-14-methoxy-13-(methoxycarbonyl)-3,5,7-trimethyl-2,4-tetradecadienoate

(2'R,3'R,7R)-(E,E)-methyl 11-<3'-(hydroxymethyl)-4'-oxo-2'-oxethanyl>-3,5,7-trimethyl-2,4-undecadienoate