diphenylmethyl 7β-acetamido>-7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate

Base Information

• Chemical Name: diphenylmethyl 7β-acetamido>-7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate
• CAS No.: 86070-54-4
• Molecular Formula: C₄₃H₄₂N₁₀O₁₂S₂
• Molecular Weight: 954.998
• Mol file: 86070-54-4.mol

Synonyms:

Chemical Property of diphenylmethyl 7β-acetamido>-7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diphenylmethyl 7β-acetamido>-7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate

There total 13 articles about diphenylmethyl 7β-acetamido>-7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Acetic acid 2-acetoxy-5-{(R)-chlorocarbonyl-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)-amino]-methyl}-phenyl ester (93589-18-5) + diphenylmethyl 7β-amino-7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate (86070-49-7) → diphenylmethyl 7β-acetamido>-7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate (86070-54-4)

Guidance literature:

With pyridine; In dichloromethane;

Reference yield:

t-butyl 7β-amino-7α-formamidocephalosporanate (86062-30-8) → diphenylmethyl 7β-acetamido>-7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate (86070-54-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / TFA / 0.5 h / Ambient temperature

2: sodium hydrogen carbonate / acetone; H₂O / 5 h / 60 °C

3: 22 percent / CH₂Cl₂; dimethylformamide / 4 h / Ambient temperature

4: 74 percent / pyridine / CH₂Cl₂

With pyridine; sodium hydrogencarbonate; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

t-butyl 7β-amino-7α-(methylthio)cephalosporanate (54820-94-9) → diphenylmethyl 7β-acetamido>-7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate (86070-54-4)

Guidance literature:

Multi-step reaction with 8 steps

1: 97 percent / pyridine / CH₂Cl₂ / 0 °C

2: 85 percent / mercury(II) acetate, ammonia / dimethylformamide / -40 degC then allowed to warm to room temperature

3: 75 percent / pyridine / CH₂Cl₂

4: 45 percent / potassium dihydrogen phosphate, zinc / 6 h

5: 98 percent / TFA / 0.5 h / Ambient temperature

6: sodium hydrogen carbonate / acetone; H₂O / 5 h / 60 °C

7: 22 percent / CH₂Cl₂; dimethylformamide / 4 h / Ambient temperature

8: 74 percent / pyridine / CH₂Cl₂

With pyridine; potassium dihydrogenphosphate; mercury(II) diacetate; ammonia; sodium hydrogencarbonate; trifluoroacetic acid; zinc; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

upstream raw materials:

Acetic acid 2-acetoxy-5-{(R)-chlorocarbonyl-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)-amino]-methyl}-phenyl ester

diphenylmethyl 7β-amino-7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate

7α-formamido cephalosporin

t-butyl 7β-amino-7α-formamidocephalosporanate

Downstream raw materials:

sodium 7β-acetamido>-7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate