(+/-)-ISORHYNCHOPHYLLINE

Base Information

Chemical Name:(+/-)-ISORHYNCHOPHYLLINE
CAS No.:39032-62-7
Molecular Formula:C₂₂H₂₈N₂O₄
Molecular Weight:384.475
Hs Code.:
Mol file:39032-62-7.mol

Synonyms:Corynoxan-16-carboxylicacid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (16E,20a)-(?à)- (9CI);Spiro[3H-indole-3,1'(5'H)-indolizine], corynoxan-16-carboxylic acid deriv.; (?à)-Isorhynchophylline

Suppliers and Price of (+/-)-ISORHYNCHOPHYLLINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(+/-)-ISORHYNCHOPHYLLINE 95.00%
5MG
$ 783.20

Total 6 raw suppliers

Chemical Property of (+/-)-ISORHYNCHOPHYLLINE

Chemical Property:

Melting Point:194 - 198 °C
Boiling Point:560.8±50.0 °C(Predicted)
PKA:13.61±0.60(Predicted)
PSA：67.87000
Density:1.23
LogP:2.77610

Purity/Quality:

≥95% ^*data from raw suppliers

(+/-)-ISORHYNCHOPHYLLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (+/-)-ISORHYNCHOPHYLLINE

There total 16 articles about (+/-)-ISORHYNCHOPHYLLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 630-94-4,51014-29-0
(±)-corynoxeine

: 76-66-4,6859-01-4,6877-32-3,17391-18-3,39032-61-6,39032-62-7
rhynchophylline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 18h; under 760.051 Torr;
DOI:10.1002/ejoc.201201505

Reference yield:

: C₂₅H₂₉N₃O₈S

: 76-66-4,6859-01-4,6877-32-3,17391-18-3,39032-61-6,39032-62-7
rhynchophylline

Guidance literature:: Multi-step reaction with 6 steps

1.1: thiophenol; potassium carbonate / dimethyl sulfoxide / 2.15 h

2.1: triethylamine / acetonitrile / 2.33 h / 20 °C

3.1: caesium carbonate; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; bis(η3-allyl-μ-chloropalladium(II)) / tetrahydrofuran / 8 h / Inert atmosphere

4.1: 6 h / 0 °C

5.1: tetrahydrofuran / 0.08 h / 20 °C

5.2: -78 - 20 °C

5.3: 20 h / 20 °C

6.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 18 h / 760.05 Torr

With bis(η3-allyl-μ-chloropalladium(II)); palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; thiophenol; triethylamine; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; acetonitrile; 5.2: |Wittig Olefination;
DOI:10.1002/ejoc.201201505

Reference yield:

: 1443767-64-3
C₁₉H₂₆N₂O₄

: 76-66-4,6859-01-4,6877-32-3,17391-18-3,39032-61-6,39032-62-7
rhynchophylline

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / acetonitrile / 2.33 h / 20 °C

2.1: caesium carbonate; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; bis(η3-allyl-μ-chloropalladium(II)) / tetrahydrofuran / 8 h / Inert atmosphere

3.1: 6 h / 0 °C

4.1: tetrahydrofuran / 0.08 h / 20 °C

4.2: -78 - 20 °C

4.3: 20 h / 20 °C

5.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 18 h / 760.05 Torr

With bis(η3-allyl-μ-chloropalladium(II)); palladium 10% on activated carbon; hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; ethyl acetate; acetonitrile; 4.2: |Wittig Olefination;
DOI:10.1002/ejoc.201201505