Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-((2S,3S,4R,5S,6S)-4,5-bis-acetylamino-2-formyl-6-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester

Base Information

• Chemical Name: Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-((2S,3S,4R,5S,6S)-4,5-bis-acetylamino-2-formyl-6-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester
• CAS No.: 297733-61-0
• Molecular Formula: C₃₄H₄₃F₃N₄O₁₅
• Molecular Weight: 804.728

Synonyms:

Chemical Property of Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-((2S,3S,4R,5S,6S)-4,5-bis-acetylamino-2-formyl-6-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-((2S,3S,4R,5S,6S)-4,5-bis-acetylamino-2-formyl-6-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester

There total 12 articles about Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-((2S,3S,4R,5S,6S)-4,5-bis-acetylamino-2-formyl-6-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4,6-O-benzylidene-1-thio-β-D-glucopyranoside (20701-61-5,56119-28-9,131564-36-8,142924-31-0,151123-92-1,141899-53-8) → Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-((2S,3S,4R,5S,6S)-4,5-bis-acetylamino-2-formyl-6-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester (297733-61-0)

Guidance literature:

Multi-step reaction with 10 steps

1.1: 50 percent / pyridine / 70 h / 20 °C

2.1: Bu₄NHSO₄; NaOH; K₂CO₃ / toluene; dimethylsulfoxide; butan-1-ol / 2 h / 20 °C

3.1: NaN₃; NH₄Cl / dimethylsulfoxide / 20 h / 80 °C

4.1: CH₂Cl₂; pyridine / 2.5 h / 0 - 20 °C

5.1: NaN₃ / dimethylsulfoxide / 0.5 h / 20 °C

6.1: 44 percent / 4 Angstroem molecular sieves; dimethyl(thiomethyl)sulfonium triflate / CH₂Cl₂ / 70 h / 20 °C

7.1: 73 percent / sodium cyanoborohydride; 3 Angstroem molecular sieves; fluoroboric acid / tetrahydrofuran; diethyl ether / 4 h / 0 °C

8.1: 2,6-di-tert-butyl-4-methylpyridine; 4 Angstroem molecular sieves; dimethyl(thiomethyl)sulfonium triflate / CH₂Cl₂ / 14 h / 20 °C

8.2: H₂S; Et₃N / pyridine; H₂O / 1.92 h

8.3: 40 percent / pyridine / 1.5 h

9.1: H₂ / 10 percent Pd-C / ethanol; ethyl acetate / 5 h

10.1: DMSO; Ac₂O / 6 h / 20 °C

With sodium hydroxide; tetrafluoroboric acid; sodium azide; 2,6-di-tert-butyl-4-methylpyridine; 3 A molecular sieve; 4 A molecular sieve; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; acetic anhydride; sodium cyanoborohydride; potassium carbonate; ammonium chloride; dimethyl sulfoxide; dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate; palladium on activated charcoal; In tetrahydrofuran; pyridine; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene; butan-1-ol; 1.1: Tosylation / 2.1: Substitution / 3.1: Substitution / 4.1: Acylation / 5.1: Substitution / 6.1: glycosylation / 7.1: Reduction / 8.1: glycosylation / 8.2: Reduction / 8.3: Acetylation / 9.1: Catalytic hydrogenation / 10.1: Oxidation;

DOI:10.1016/S0008-6215(99)00318-3

Reference yield:

2-[4-(trifluoroacetylamino)phenyl]ethanol (115166-92-2) → Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-((2S,3S,4R,5S,6S)-4,5-bis-acetylamino-2-formyl-6-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester (297733-61-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 44 percent / 4 Angstroem molecular sieves; dimethyl(thiomethyl)sulfonium triflate / CH₂Cl₂ / 70 h / 20 °C

2.1: 73 percent / sodium cyanoborohydride; 3 Angstroem molecular sieves; fluoroboric acid / tetrahydrofuran; diethyl ether / 4 h / 0 °C

3.1: 2,6-di-tert-butyl-4-methylpyridine; 4 Angstroem molecular sieves; dimethyl(thiomethyl)sulfonium triflate / CH₂Cl₂ / 14 h / 20 °C

3.2: H₂S; Et₃N / pyridine; H₂O / 1.92 h

3.3: 40 percent / pyridine / 1.5 h

4.1: H₂ / 10 percent Pd-C / ethanol; ethyl acetate / 5 h

5.1: DMSO; Ac₂O / 6 h / 20 °C

With tetrafluoroboric acid; 2,6-di-tert-butyl-4-methylpyridine; 3 A molecular sieve; 4 A molecular sieve; hydrogen; acetic anhydride; sodium cyanoborohydride; dimethyl sulfoxide; dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; ethyl acetate; 1.1: glycosylation / 2.1: Reduction / 3.1: glycosylation / 3.2: Reduction / 3.3: Acetylation / 4.1: Catalytic hydrogenation / 5.1: Oxidation;

DOI:10.1016/S0008-6215(99)00318-3

Reference yield:

(1aR,2S,3aR,6R,7aR,7bR)-2-Ethylsulfanyl-6-phenyl-hexahydro-1,3,5,7-tetraoxa-cyclopropa[a]naphthalene (297733-53-0) → Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-((2S,3S,4R,5S,6S)-4,5-bis-acetylamino-2-formyl-6-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester (297733-61-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: NaN₃; NH₄Cl / dimethylsulfoxide / 20 h / 80 °C

2.1: CH₂Cl₂; pyridine / 2.5 h / 0 - 20 °C

3.1: NaN₃ / dimethylsulfoxide / 0.5 h / 20 °C

4.1: 44 percent / 4 Angstroem molecular sieves; dimethyl(thiomethyl)sulfonium triflate / CH₂Cl₂ / 70 h / 20 °C

5.1: 73 percent / sodium cyanoborohydride; 3 Angstroem molecular sieves; fluoroboric acid / tetrahydrofuran; diethyl ether / 4 h / 0 °C

6.1: 2,6-di-tert-butyl-4-methylpyridine; 4 Angstroem molecular sieves; dimethyl(thiomethyl)sulfonium triflate / CH₂Cl₂ / 14 h / 20 °C

6.2: H₂S; Et₃N / pyridine; H₂O / 1.92 h

6.3: 40 percent / pyridine / 1.5 h

7.1: H₂ / 10 percent Pd-C / ethanol; ethyl acetate / 5 h

8.1: DMSO; Ac₂O / 6 h / 20 °C

With tetrafluoroboric acid; sodium azide; 2,6-di-tert-butyl-4-methylpyridine; 3 A molecular sieve; 4 A molecular sieve; hydrogen; acetic anhydride; sodium cyanoborohydride; ammonium chloride; dimethyl sulfoxide; dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate; palladium on activated charcoal; In tetrahydrofuran; pyridine; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; 1.1: Substitution / 2.1: Acylation / 3.1: Substitution / 4.1: glycosylation / 5.1: Reduction / 6.1: glycosylation / 6.2: Reduction / 6.3: Acetylation / 7.1: Catalytic hydrogenation / 8.1: Oxidation;

DOI:10.1016/S0008-6215(99)00318-3

upstream raw materials:

ethyl 4,6-O-benzylidene-1-thio-β-D-glucopyranoside

2-[4-(trifluoroacetylamino)phenyl]ethanol

(1aR,2S,3aR,6R,7aR,7bR)-2-Ethylsulfanyl-6-phenyl-hexahydro-1,3,5,7-tetraoxa-cyclopropa[a]naphthalene

ethyl 2-azido-4,6-O-benzylidene-2-deoxy-1-thio-β-D-altropyranoside

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 297733-61-0 Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-((2S,3S,4R,5S,6S)-4,5-bis-acetylamino-2-formyl-6-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send