4-(2-Allyl-phenyl)-3-(2-diazo-2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyrimidine-1,5-dicarboxylic acid 1-benzyl ester 5-ethyl ester

Base Information

Chemical Name:4-(2-Allyl-phenyl)-3-(2-diazo-2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyrimidine-1,5-dicarboxylic acid 1-benzyl ester 5-ethyl ester
CAS No.:223440-43-5
Molecular Formula:C₂₉H₂₈N₄O₈
Molecular Weight:560.563
Hs Code.:

4-(2-Allyl-phenyl)-3-(2-diazo-2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyrimidine-1,5-dicarboxylic acid 1-benzyl ester 5-ethyl ester

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Chemical Property of 4-(2-Allyl-phenyl)-3-(2-diazo-2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyrimidine-1,5-dicarboxylic acid 1-benzyl ester 5-ethyl ester

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Technology Process of 4-(2-Allyl-phenyl)-3-(2-diazo-2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyrimidine-1,5-dicarboxylic acid 1-benzyl ester 5-ethyl ester

There total 5 articles about 4-(2-Allyl-phenyl)-3-(2-diazo-2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyrimidine-1,5-dicarboxylic acid 1-benzyl ester 5-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 223440-41-3
4-(2-Allyl-phenyl)-3-(2-diazo-2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

: 223440-43-5
4-(2-Allyl-phenyl)-3-(2-diazo-2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyrimidine-1,5-dicarboxylic acid 1-benzyl ester 5-ethyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; 1.) 0 deg C, 2.) r.t.;
DOI:10.1039/a808594c

Reference yield:

: 62708-42-3
o-allylbenzaldehyde

: 223440-43-5
4-(2-Allyl-phenyl)-3-(2-diazo-2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyrimidine-1,5-dicarboxylic acid 1-benzyl ester 5-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 39 percent / HCl / methanol / 15 h / Heating

2: 91 percent / benzene / Heating

3: 82 percent / mesyl azide, Et₃N / CH₂Cl₂

4: 69 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 2.) r.t.

With hydrogenchloride; sodium hydride; triethylamine; Methanesulfonyl azide; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1039/a808594c

Reference yield:

: 141-97-9
ethyl acetoacetate

: 223440-43-5
4-(2-Allyl-phenyl)-3-(2-diazo-2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyrimidine-1,5-dicarboxylic acid 1-benzyl ester 5-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 39 percent / HCl / methanol / 15 h / Heating

2: 91 percent / benzene / Heating

3: 82 percent / mesyl azide, Et₃N / CH₂Cl₂

4: 69 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 2.) r.t.

With hydrogenchloride; sodium hydride; triethylamine; Methanesulfonyl azide; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1039/a808594c