Methyl 6-aMinoindole-4-carboxylate hydrochloride, 97%

Base Information

• Chemical Name: Methyl 6-aMinoindole-4-carboxylate hydrochloride, 97%
• CAS No.: 731810-08-5
• Molecular Formula: C₁₀H₁₀N₂O₂*ClH
• Molecular Weight: 226.663
• Hs Code.: 2933990090
• Mol file: 731810-08-5.mol

Synonyms:1H-Indole-4-carboxylicacid, 6-amino-, methyl ester, monohydrochloride (9CI)

Chemical Property of Methyl 6-aMinoindole-4-carboxylate hydrochloride, 97%

Chemical Property:

• Melting Point: >230℃
• PSA: 68.11000
• LogP: 2.91990
• Storage Temp.: Sealed in dry,Room Temperature
• Sensitive.: Hygroscopic

Purity/Quality:

99% ^*data from raw suppliers

Methyl6-Amino-1H-indole-4-carboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 6-aminoindole-4-carboxylate hydrochloride is used as an organic chemical synthesis intermediate.

Technology Process of Methyl 6-aMinoindole-4-carboxylate hydrochloride, 97%

There total 3 articles about Methyl 6-aMinoindole-4-carboxylate hydrochloride, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(E)-methyl 2-(2-(dimethylamino)vinyl)-3,5-dinitrobenzoate → 6-amino-1H-indole-4-carboxylic acid methyl ester hydrochloride (731810-08-5)

Guidance literature:

(E)-methyl 2-(2-(dimethylamino)vinyl)-3,5-dinitrobenzoate; With hydrogen; palladium 10% on activated carbon; In methanol; water; ethyl acetate; at 0 ℃; for 2h; under 2585.81 - 3102.97 Torr;

With hydrogenchloride; In water; ethyl acetate; at 10 ℃; for 1h; Product distribution / selectivity;

Reference yield:

3,5-diamino-2-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester (952238-94-7) → 6-amino-1H-indole-4-carboxylic acid methyl ester hydrochloride (731810-08-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h;

Reference yield:

2-(2,2-dimethoxy-ethyl)-3,5-dinitro-benzoic acid methyl ester (731810-07-4) → 6-amino-1H-indole-4-carboxylic acid methyl ester hydrochloride (731810-08-5)

Guidance literature:

2-(2,2-dimethoxy-ethyl)-3,5-dinitro-benzoic acid methyl ester; With ammonium formate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; at 35 - 45 ℃; for 0.666667h;

With hydrogenchloride; In methanol; water; at 32 - 35 ℃; for 3h; Product distribution / selectivity;

upstream raw materials:

2-(2,2-dimethoxy-ethyl)-3,5-dinitro-benzoic acid methyl ester

3,5-diamino-2-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester

Downstream raw materials:

methyl 6-((tert-butoxycarbonyl)amino)-1H-indole-4-carboxylate

Refernces

• 1、 -. "DIAZEPINOINDOLE DERIVATIVES AS KINASE INHIBITORS". Page 73-74. . Retrieved 2008/06/13.