5-Bromo-2-(difluoromethoxy)benzaldehyde

Base Information

Chemical Name:5-Bromo-2-(difluoromethoxy)benzaldehyde
CAS No.:329269-64-9
Molecular Formula:C8H5 Br F2 O2
Molecular Weight:251.02500
Hs Code.:2913000090
European Community (EC) Number:840-520-2
DSSTox Substance ID:DTXSID70366428
Wikidata:Q82151639
Mol file:329269-64-9.mol

Synonyms:5-bromo-2-(difluoromethoxy)benzaldehyde;329269-64-9;Benzaldehyde,5-bromo-2-(difluoromethoxy)-;SCHEMBL868657;DTXSID70366428;CL9243;MFCD02709888;5-bromo-2-difluoromethoxy-benzaldehyde;AKOS001021139;AS-46258;CS-0138987;EN300-07859;A913245;5-bromo-2-(difluoromethoxy)benzaldehyde, AldrichCPR;Z55671924

Suppliers and Price of 5-Bromo-2-(difluoromethoxy)benzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
5-BROMO-2-(DIFLUOROMETHOXY)BENZALDEHYDE 95
5g
$ 1217.00

Chemenu
5-bromo-2-(difluoromethoxy)benzaldehyde 95%
10g
$ 411.00

American Custom Chemicals Corporation
5-BROMO-2-(DIFLUOROMETHOXY)BENZALDEHYDE 95.00%
5G
$ 1548.26

American Custom Chemicals Corporation
5-BROMO-2-(DIFLUOROMETHOXY)BENZALDEHYDE 95.00%
2.5G
$ 1227.82

American Custom Chemicals Corporation
5-BROMO-2-(DIFLUOROMETHOXY)BENZALDEHYDE 95.00%
1G
$ 852.55

Alichem
5-Bromo-2-(difluoromethoxy)benzaldehyde
1g
$ 1579.40

Alichem
5-Bromo-2-(difluoromethoxy)benzaldehyde
250mg
$ 499.20

AK Scientific
5-Bromo-2-(difluoromethoxy)benzaldehyde
100mg
$ 273.00

AK Scientific
5-Bromo-2-(difluoromethoxy)benzaldehyde
2.5g
$ 419.00

Total 9 raw suppliers

Chemical Property of 5-Bromo-2-(difluoromethoxy)benzaldehyde

Chemical Property:

PSA：26.30000
LogP:2.86300
Storage Temp.:2-8°C
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:249.94410
Heavy Atom Count:13
Complexity:178

Purity/Quality:

97% ^*data from raw suppliers

5-BROMO-2-(DIFLUOROMETHOXY)BENZALDEHYDE 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1Br)C=O)OC(F)F

Technology Process of 5-Bromo-2-(difluoromethoxy)benzaldehyde

There total 1 articles about 5-Bromo-2-(difluoromethoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: S-difluoromethyl-S-phenyl-2,4,6-trimethoxyphenylsulfonium tetrafluoroborate

: 1761-61-1
5-bromosalicyclaldehyde

: 329269-64-9
5-bromo-2-(difluoromethoxy)benzaldehyde

Guidance literature:: 5-bromosalicyclaldehyde; With lithium hydroxide; In fluorobenzene; at 20 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

S-difluoromethyl-S-phenyl-2,4,6-trimethoxyphenylsulfonium tetrafluoroborate; In fluorobenzene; at 20 ℃; chemoselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1021/acs.joc.9b02424

Reference yield:

: 109-87-5
Dimethoxymethane

: 329269-64-9
5-bromo-2-(difluoromethoxy)benzaldehyde

: 1623766-68-6
4-bromo-1-(difluoromethoxy)-2-((methoxymethoxy)methyl)benzene

Guidance literature:: 5-bromo-2-(difluoromethoxy)benzaldehyde; With sodium tetrahydroborate; In methanol; for 0.5h; Cooling with ice;

Dimethoxymethane; With phosphorus pentoxide; In dichloromethane; for 0.5h; Cooling with ice;

Reference yield:

: 329269-64-9
5-bromo-2-(difluoromethoxy)benzaldehyde

: 1623766-69-7
2-(4-(difluoromethoxy)-3-((methoxymethoxy)methyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol / 0.5 h / Cooling with ice

1.2: 0.5 h / Cooling with ice

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / N,N-dimethyl-formamide / 2 h / 20 - 110 °C

With sodium tetrahydroborate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In methanol; N,N-dimethyl-formamide;