C₁₀H₆ClNO₃

Base Information

• Chemical Name: C₁₀H₆ClNO₃
• CAS No.: 1352006-99-5
• Molecular Formula: C₁₀H₆ClNO₃
• Molecular Weight: 223.616
• Mol file: 1352006-99-5.mol

Synonyms:

Chemical Property of C₁₀H₆ClNO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₆ClNO₃

There total 4 articles about C₁₀H₆ClNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (625470-33-9) → C10H6ClNO3 (1352006-99-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 80 °C / Molecular sieve

2: methanol; sodium hydroxide

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; sodium hydroxide; In 1,4-dioxane; 1: Suzuki reaction;

DOI:10.1016/j.bmcl.2011.06.117

Reference yield:

5-bromo-2-chlorobenzoic acid (21739-92-4) → C10H6ClNO3 (1352006-99-5)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / water

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / Heating

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 80 °C / Molecular sieve

4: methanol; sodium hydroxide

With hydrogenchloride; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; caesium carbonate; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide; 3: Suzuki reaction;

DOI:10.1016/j.bmcl.2011.06.117

Reference yield:

methyl 5-bromo-2-chloro-benzoate (251085-87-7) → C10H6ClNO3 (1352006-99-5)

Guidance literature:

Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / Heating

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 80 °C / Molecular sieve

3: methanol; sodium hydroxide

With methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; caesium carbonate; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; 2: Suzuki reaction;

DOI:10.1016/j.bmcl.2011.06.117

upstream raw materials:

methyl 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

C₁₁H₈ClNO₃

5-bromo-2-chlorobenzoic acid

methyl 5-bromo-2-chloro-benzoate

Downstream raw materials:

C₁₈H₂₁ClN₂O₃