apratoxin S₁

Base Information

Chemical Name:apratoxin S₁
CAS No.:1334149-91-5
Molecular Formula:C₄₂H₆₃N₅O₈S
Molecular Weight:798.057
Hs Code.:

Synonyms:

Suppliers and Price of apratoxin S₁

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of apratoxin S₁

Chemical Property:

Purity/Quality:

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Technology Process of apratoxin S₁

There total 21 articles about apratoxin S₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₂H₆₅N₅O₉S

: 1334149-91-5
apratoxin S₁

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 - 20 ℃; for 20.5h;
DOI:10.1021/ml200176m

Reference yield:

: (E)-(S)-4-Amino-2-methyl-5-tritylsulfanyl-pent-2-enoic acid allyl ester

: 1334149-91-5
apratoxin S₁

Guidance literature:: Multi-step reaction with 8 steps

1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 0 °C

2: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3: ammonium acetate; zinc / tetrahydrofuran; water / 0.5 h / 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methylaniline / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Darkness

5: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 10 h / 20 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methylaniline / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Darkness

7: diethylamine / acetonitrile

8: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20.5 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; trifluoromethylsulfonic anhydride; ammonium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; HATU; N-methylaniline; Triphenylphosphine oxide; zinc; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/ml200176m

Reference yield:

: (S,E)-4-((tert-butoxycarbonyl)amino)-2-methyl-5-(tritylthio)pent-2-enoic acid

: 1334149-91-5
apratoxin S₁

Guidance literature:: Multi-step reaction with 10 steps

1: potassium carbonate / dimethyl sulfoxide / 20 °C

2: 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere

3: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 0 °C

4: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5: ammonium acetate; zinc / tetrahydrofuran; water / 0.5 h / 20 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methylaniline / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Darkness

7: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 10 h / 20 °C

8: tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methylaniline / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Darkness

9: diethylamine / acetonitrile

10: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20.5 h / 0 - 20 °C

With 2,6-dimethylpyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; trifluoromethylsulfonic anhydride; trimethylsilyl trifluoromethanesulfonate; ammonium acetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; HATU; N-methylaniline; Triphenylphosphine oxide; zinc; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/ml200176m