3-(4-CHLORO-PHENYL)-3,3-DIFLUORO-2-HYDROXY-PROPIONIC ACID

Base Information

• Chemical Name: 3-(4-CHLORO-PHENYL)-3,3-DIFLUORO-2-HYDROXY-PROPIONIC ACID
• CAS No.: 517920-76-2
• Molecular Formula: C₉H₇ClF₂O₃
• Molecular Weight: 236.603
• Hs Code.: 2918199890
• Mol file: 517920-76-2.mol

Synonyms:

Chemical Property of 3-(4-CHLORO-PHENYL)-3,3-DIFLUORO-2-HYDROXY-PROPIONIC ACID

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-(4-CHLOROPHENYL)-3,3-DIFLUORO-2-HYDROXYPROPIONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 3-(4-CHLORO-PHENYL)-3,3-DIFLUORO-2-HYDROXY-PROPIONIC ACID

There total 11 articles about 3-(4-CHLORO-PHENYL)-3,3-DIFLUORO-2-HYDROXY-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

3-(4-chlorophenyl)-3,3-difluoro-2-oxopropionic acid (742692-47-3) → 3-(4-chlorophenyl)-3,3-difluoro-2-hydroxypropionic acid (517920-76-2) + 2-amino-3-(4-chlorophenyl)-3,3-difluoropropionic acid

Guidance literature:

3-(4-chlorophenyl)-3,3-difluoro-2-oxopropionic acid; With ammonium hydroxide; at 60 ℃;

With sodium tetrahydroborate; In water; at 25 ℃; Further stages.;

DOI:10.1016/j.tet.2004.06.086

Reference yield:

1-Chloro-4-(1-fluorovinyl)benzene (106263-12-1) → 3-(4-chlorophenyl)-3,3-difluoro-2-hydroxypropionic acid (517920-76-2)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 83 percent / Et₃N*3HF; N-bromosuccinimide / CH₂Cl₂ / 25 °C

2.1: 78 percent / 1,4,7,10,13,16-hexaoxacyclooctadecane / dimethylformamide / 150 °C

3.1: 94 percent / aq. NaOH / ethanol / 25 °C

4.1: 99 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 25 °C

5.1: 69 percent / aq. sodium metabisulfite / 25 °C

6.1: 77 percent / HCl / 25 °C

7.1: 89 percent / 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one / CH₂Cl₂ / 25 °C

8.1: 87 percent / aq. NaHCO₃ / propan-2-ol / 50 °C

9.1: aq. NH₃ / 60 °C

9.2: 64 percent / NaBH₄ / H₂O / 25 °C

With hydrogenchloride; ammonium hydroxide; sodium hydroxide; sodium disulfite; N-Bromosuccinimide; oxalyl dichloride; 18-crown-6 ether; sodium hydrogencarbonate; Dess-Martin periodane; dimethyl sulfoxide; triethylamine tris(hydrogen fluoride); triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; 4.1: Swern oxidation / 7.1: Dess-Martin oxidation;

DOI:10.1016/j.tet.2004.06.086

Reference yield:

1-(2-Bromo-1-fluoroethyl)-4-chlorobenzene (242148-56-7) → 3-(4-chlorophenyl)-3,3-difluoro-2-hydroxypropionic acid (517920-76-2)

Guidance literature:

Multi-step reaction with 10 steps

1.1: 84 percent / t-BuOK / tetrahydrofuran / 25 °C

2.1: 83 percent / Et₃N*3HF; N-bromosuccinimide / CH₂Cl₂ / 25 °C

3.1: 78 percent / 1,4,7,10,13,16-hexaoxacyclooctadecane / dimethylformamide / 150 °C

4.1: 94 percent / aq. NaOH / ethanol / 25 °C

5.1: 99 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 25 °C

6.1: 69 percent / aq. sodium metabisulfite / 25 °C

7.1: 77 percent / HCl / 25 °C

8.1: 89 percent / 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one / CH₂Cl₂ / 25 °C

9.1: 87 percent / aq. NaHCO₃ / propan-2-ol / 50 °C

10.1: aq. NH₃ / 60 °C

10.2: 64 percent / NaBH₄ / H₂O / 25 °C

With hydrogenchloride; ammonium hydroxide; sodium hydroxide; sodium disulfite; N-Bromosuccinimide; oxalyl dichloride; 18-crown-6 ether; potassium tert-butylate; sodium hydrogencarbonate; Dess-Martin periodane; dimethyl sulfoxide; triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; 5.1: Swern oxidation / 8.1: Dess-Martin oxidation;

DOI:10.1016/j.tet.2004.06.086

upstream raw materials:

3-(4-chlorophenyl)-3,3-difluoro-2-oxopropionic acid

4-vinylbenzyl chloride

1-Chloro-4-(1-fluorovinyl)benzene

1-(2-Bromo-1-fluoroethyl)-4-chlorobenzene