(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[2-(4-fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

Base Information

• Chemical Name: (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[2-(4-fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester
• CAS No.: 129122-71-0
• Molecular Formula: C₄₄H₄₇FNO₅PSi
• Molecular Weight: 747.919

Synonyms:

Chemical Property of (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[2-(4-fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[2-(4-fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

There total 16 articles about (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[2-(4-fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-(4'-fluorophenyl)-3-oxopropionate (1999-00-4) → (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[2-(4-fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester (129122-71-0)

Guidance literature:

Multi-step reaction with 7 steps

1: EtONa / ethanol / 4.5 h / Ambient temperature

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

4: Dess-Martin periodinane, tert-butyl alcohol / CH₂Cl₂ / 0.5 h / Ambient temperature

5: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

6: n-BuLi / tetrahydrofuran / 1 h / -78 °C

7: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 30 min

With lithium aluminium tetrahydride; n-butyllithium; copper diacetate; ammonium acetate; sodium ethanolate; Dess-Martin periodane; triphenylphosphine; tert-butyl alcohol; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;

DOI:10.1021/jm00113a019

Reference yield:

(E)-4-methyl-1-phenyl-2-penten-1-one (36597-08-7) → (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[2-(4-fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester (129122-71-0)

Guidance literature:

Multi-step reaction with 7 steps

1: EtONa / ethanol / 4.5 h / Ambient temperature

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

4: Dess-Martin periodinane, tert-butyl alcohol / CH₂Cl₂ / 0.5 h / Ambient temperature

5: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

6: n-BuLi / tetrahydrofuran / 1 h / -78 °C

7: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 30 min

With lithium aluminium tetrahydride; n-butyllithium; copper diacetate; ammonium acetate; sodium ethanolate; Dess-Martin periodane; triphenylphosphine; tert-butyl alcohol; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;

DOI:10.1021/jm00113a019

Reference yield:

2-(4-fluorophenyl)-4-(1-methylethyl)-6-phenyl-3-pyridinemethanol (122253-01-4) → (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[2-(4-fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester (129122-71-0)

Guidance literature:

Multi-step reaction with 4 steps

1: Dess-Martin periodinane, tert-butyl alcohol / CH₂Cl₂ / 0.5 h / Ambient temperature

2: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

3: n-BuLi / tetrahydrofuran / 1 h / -78 °C

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 30 min

With n-butyllithium; Dess-Martin periodane; triphenylphosphine; tert-butyl alcohol; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00113a019

upstream raw materials:

(S)-4-(Methoxychlorophosphinyl)-3-[[(t-butyl)diphenylsilyl]oxy]-butanoic acid, methyl ester

3-Ethynyl-2-(4-fluorophenyl)-4-(1-methylethyl)-6-phenylpyridine

ethyl 3-(4'-fluorophenyl)-3-oxopropionate

(E)-4-methyl-1-phenyl-2-penten-1-one

Downstream raw materials:

(S)-4-{[2-(4-Fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-3-hydroxy-butyric acid methyl ester

(S)-4-[[[2-(4-Fluorophenyl)-4-(1-methylethyl)-6-phenyl-3-pyridinyl]ethynyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, dilithium salt

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 129122-71-0 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[2-(4-fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send