4-Pyridinemethanamine,2-amino-(9CI)

Base Information

• Chemical Name: 4-Pyridinemethanamine,2-amino-(9CI)
• CAS No.: 199296-51-0
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.158
• Mol file: 199296-51-0.mol

Synonyms:2-Amino-4-aminomethylpyridine;4-Aminomethylpyridin-2-ylamine;4-(Aminomethyl)pyridin-2-amine;

Chemical Property of 4-Pyridinemethanamine,2-amino-(9CI)

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.624
• Boiling Point: 301.009 °C at 760 mmHg
• Flash Point: 161.142 °C
• PSA: 64.93000
• Density: 1.174 g/cm³
• LogP: 1.40400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

4-Aminomethyl-pyridin-2-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridinemethanamine,2-amino-(9CI)

There total 1 articles about 4-Pyridinemethanamine,2-amino-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-cyanopyridin-2-amine (42182-27-4) → 2-amino-4-aminomethylpyridine (199296-51-0)

Guidance literature:

With hydrogen; triethylamine; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 12h; under 2585.81 Torr;

Reference yield: 33.0%

2-amino-4-aminomethylpyridine (199296-51-0) + N-(2-chlorophenyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carbothioamide → 4-{[(2-aminopyridin-4-yl)methyl]amino}-N-(2-chlorophenyl)-2-oxo-1,2,5,6-tetrahydropyridine-3-carbothioamide

Guidance literature:

In ethanol; at 100 ℃; for 16h; Microwave irradiation;

Reference yield: 17.0%

2-amino-4-aminomethylpyridine (199296-51-0) + 1-cyclopropyl-4-hydroxy-2-oxo-N-phenyl-1,2,5,6-tetrahydropyridine-3-carbothioamide → 4-{[(2-aminopyridin-4-yl)methyl]amino}-1-cyclopropyl-2-oxo-N-phenyl-1,2,5,6-tetrahydropyridine-3-carbothioamide

Guidance literature:

In N,N-dimethyl acetamide; at 130 ℃; for 1h; Microwave irradiation;

upstream raw materials:

4-cyanopyridin-2-amine

Downstream raw materials:

tert-butyl N-[(2-aminopyridin-4-yl)methyl]carbamate

[3-amino-6-(2,4-dichloro-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-7-ylmethyl]-carbamic acid tert-butyl ester