Technology Process of 3-(4-methylpiperazin-1-yl)-5-(3-nitrophenyl)quinoline
There total 5 articles about 3-(4-methylpiperazin-1-yl)-5-(3-nitrophenyl)quinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate;
In
tetrahydrofuran; water;
for 2h;
DOI:10.1021/jm101340q
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 8 h / 110 °C / Inert atmosphere
2.1: iron; ammonium chloride / ethanol; water / Reflux
3.1: tetrafluoroboric acid; isopentyl nitrite / acetone / 1 h / -8 °C / Inert atmosphere
3.2: 2 h
4.1: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 2 h
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tetrafluoroboric acid; iron; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; isopentyl nitrite;
In
tetrahydrofuran; ethanol; water; acetone; toluene;
1.1: Buchwald-Hartwig coupling / 4.1: Suzuki coupling;
DOI:10.1021/jm101340q
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: iron; ammonium chloride / ethanol; water / Reflux
2.1: tetrafluoroboric acid; isopentyl nitrite / acetone / 1 h / -8 °C / Inert atmosphere
2.2: 2 h
3.1: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 2 h
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tetrafluoroboric acid; iron; ammonium chloride; isopentyl nitrite;
In
tetrahydrofuran; ethanol; water; acetone;
3.1: Suzuki coupling;
DOI:10.1021/jm101340q
