(E)-(4R,5S,6R,7S,8R)-5-Acetylamino-4-benzyloxy-6,7,8,9-tetrahydroxy-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-non-2-enoic acid methyl ester

Base Information

• Chemical Name: (E)-(4R,5S,6R,7S,8R)-5-Acetylamino-4-benzyloxy-6,7,8,9-tetrahydroxy-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-non-2-enoic acid methyl ester
• CAS No.: 93070-33-8
• Molecular Formula: C₄₇H₅₇NO₁₄
• Molecular Weight: 859.968

Synonyms:

Chemical Property of (E)-(4R,5S,6R,7S,8R)-5-Acetylamino-4-benzyloxy-6,7,8,9-tetrahydroxy-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-non-2-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(4R,5S,6R,7S,8R)-5-Acetylamino-4-benzyloxy-6,7,8,9-tetrahydroxy-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-non-2-enoic acid methyl ester

There total 14 articles about (E)-(4R,5S,6R,7S,8R)-5-Acetylamino-4-benzyloxy-6,7,8,9-tetrahydroxy-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-non-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(E)-(4S,5R)-5-Acetylamino-4-benzyloxy-5-((4S,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-pent-2-enoic acid methyl ester (93070-32-7,93218-73-6) → (E)-(4R,5S,6R,7S,8R)-5-Acetylamino-4-benzyloxy-6,7,8,9-tetrahydroxy-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-non-2-enoic acid methyl ester (93070-33-8,93133-56-3)

Guidance literature:

With water; trifluoroacetic acid; at 0 ℃; for 0.5h;

DOI:10.1016/0040-4039(84)80010-6

Reference yield: 80.0%

(Z)-(4S,5R)-5-Acetylamino-4-benzyloxy-5-((4S,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-pent-2-enoic acid methyl ester (93070-32-7,93218-73-6) → (Z)-(4R,5S,6R,7S,8R)-5-Acetylamino-4-benzyloxy-6,7,8,9-tetrahydroxy-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-non-2-enoic acid methyl ester (93070-33-8,93133-56-3)

Guidance literature:

With water; trifluoroacetic acid; at 0 ℃; for 0.5h;

DOI:10.1016/0040-4039(84)80010-6

Reference yield:

methyl 2,3,4-tri-O-benzyl-D-glucopyranoside (53008-65-4,641635-63-4) → (E)-(4R,5S,6R,7S,8R)-5-Acetylamino-4-benzyloxy-6,7,8,9-tetrahydroxy-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-non-2-enoic acid methyl ester (93070-33-8,93133-56-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / rhodium acetate / benzene / 2 h / Heating

2: 30 percent / NaH / tetrahydrofuran / 1 h / 0 °C

3: 80 percent / CF₃COOH/H₂O (9:1) / 0.5 h / 0 °C

With water; sodium hydride; trifluoroacetic acid; rhodium(II) acetate; In tetrahydrofuran; benzene;

DOI:10.1016/0040-4039(84)80010-6

upstream raw materials:

(Z)-(4S,5R)-5-Acetylamino-4-benzyloxy-5-((4S,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-pent-2-enoic acid methyl ester

methyl 2,3,4-tri-O-benzyl-D-glucopyranoside

N-[(1R,2R)-3,3-Bis-ethylsulfanyl-2-hydroxy-1-((4S,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-propyl]-acetamide

benzyl bromide

Downstream raw materials:

(4S,5R,6R)-5-Acetylamino-4-benzyloxy-6-((1S,2S)-1,2,3-trihydroxy-propyl)-5,6-dihydro-4H-pyran-2-carboxylic acid methyl ester

(2S,4S,5R,6R)-5-Acetylamino-4-benzyloxy-6-((1S,2S)-1,2,3-trihydroxy-propyl)-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

(2R,4S,5R,6R)-5-Acetylamino-4-benzyloxy-6-((1S,2S)-1,2,3-trihydroxy-propyl)-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

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