2,3-Dihydro-1H-pyrrolo[3,4-C]pyridine hydrochloride

Base Information

• Chemical Name: 2,3-Dihydro-1H-pyrrolo[3,4-C]pyridine hydrochloride
• CAS No.: 651558-58-6
• Molecular Formula: C₇H₈N₂*ClH
• Molecular Weight: 156.615
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40596816
• Mol file: 651558-58-6.mol

Synonyms:651558-58-6;2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDINE HYDROCHLORIDE;2,3-dihydro-1h-pyrrolo[3,4-c]pyridine hcl;1255306-33-2;2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine xhydrochloride;1H,2H,3H-pyrrolo[3,4-c]pyridine hydrochloride;MFCD08273906;2,3-dihydro-1H-pyrrolo[3,4-c]pyridine;hydrochloride;2,3-Dihydro-1h-pyrrolo[3,4-c]pyridine, HCl;2,3-Dihydro-1H-pyrrolo[3,4-c]pyridinehydrochloride;1H-Pyrrolo[3,4-c]pyridine, 2,3-dihydro-, monohydrochloride;SCHEMBL793721;DTXSID40596816;PDMGKSJRAQJZDN-UHFFFAOYSA-N;AMY25011;CS-D0313;AKOS015844701;AS-42043;SY006966;DB-027559;2,3-Dihydro-1H-pyrrolo[3,4-c]pyridinexhydrochloride;2,3-dihydro-1H-pyrrolo[3,4-c]pyridine hydrochloride salt;2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine monohydrochloride;1H-Pyrrolo[3,4-c]pyridine,2,3-dihydro-,hydrochloride(1:1);2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine--hydrogen chloride (1/1);2 pound not3-Dihydro-1H-pyrrolo[3 pound not4-c]pyridine hydrochloride

Chemical Property of 2,3-Dihydro-1H-pyrrolo[3,4-C]pyridine hydrochloride

Chemical Property:

• Vapor Pressure: 0.0172mmHg at 25°C
• Boiling Point: 250.4 °C at 760 mmHg
• Flash Point: 105.2 °C
• PSA: 24.92000
• LogP: 1.81560
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 156.0454260
• Heavy Atom Count: 10
• Complexity: 103

Purity/Quality:

97% ^*data from raw suppliers

2,3-Dihydro-1h-pyrrolo[3,4-c]pyridinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=C(CN1)C=NC=C2.Cl
• Uses: 2,3-Dihydro-1h-pyrrolo[3,4-c]pyridine, HCl

Technology Process of 2,3-Dihydro-1H-pyrrolo[3,4-C]pyridine hydrochloride

There total 1 articles about 2,3-Dihydro-1H-pyrrolo[3,4-C]pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(N-ethoxycarbonyl-N-propargylaminomethyl)-pyrazine → 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride salt (147740-02-1,651558-51-9) + 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine hydrochloride (651558-58-6)

Guidance literature:

(N-ethoxycarbonyl-N-propargylaminomethyl)-pyrazine; In various solvent(s); at 180 ℃;

With hydrogenchloride; Heating;

DOI:10.1016/j.bmcl.2003.08.031

Reference yield:

2,3-dihydro-1H-pyrrolo[3,4-c]pyridine dihydrogen chloride (6000-50-6,651558-58-6) → (R)-1-(4-chloro-3-(4-(3,5-dimethylisoxazol-4-yl)-5-methyl-6-(5-(2,2,2-trifluoroethyl)-1,3,4,5,6,7-hexahydro-2H-pyrrolo[3,4-c]pyridin-2-yl)pyrimidin-2-yl)phenoxy)-3-(methylamino)propan-2-ol

Guidance literature:

Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: acetonitrile / 4 h / 80 °C

3: sodium cyanoborohydride / methanol / 16 h / 20 °C

4: dichloromethane / 2 h / 20 °C

5: triethylamine / butan-1-ol / 2 h / 145 °C / Microwave irradiation

6: trifluoroacetic acid / water / 16 h / 20 °C

With sodium cyanoborohydride; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; water; acetonitrile; butan-1-ol;

Reference yield:

2,3-dihydro-1H-pyrrolo[3,4-c]pyridine dihydrogen chloride (6000-50-6,651558-58-6) → tert-butyl (R)-2-(tert-butyldimethylsilyloxy)-3-(4-chloro-3-(4-(3,5-dimethylisoxazol-4-yl)-5-methyl-6-(5-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,4-c]pyridin-2(3H)-yl)pyrimidin-2-yl)phenoxy)propyl(methyl)carbamate

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: acetonitrile / 4 h / 80 °C

3: sodium cyanoborohydride / methanol / 16 h / 20 °C

4: dichloromethane / 2 h / 20 °C

5: triethylamine / butan-1-ol / 2 h / 145 °C / Microwave irradiation

With sodium cyanoborohydride; triethylamine; In methanol; dichloromethane; acetonitrile; butan-1-ol;